Watching the emergence of hematopoietic stem cells

Latest research

1. 1. Neuroscience

   Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells

   Dominic Gonschorek, Matías A. Goldin ... Thomas Euler
2. 1. Stem Cells and Regenerative Medicine

   Dynamic Tracking of Native Polyclonal Hematopoiesis in Adult Mice

   Suying Liu, Sarah E. Adams ... Peter Kurre
3. 1. Neuroscience

   Stochastic characterization of navigation strategies in an automated variant of the Barnes maze

   Ju-Young Lee, Dahee Jung, Sébastien Royer
4. 1. Chromosomes and Gene Expression
   2. Neuroscience

   Molecular basis of neurodegeneration in a mouse model of Polr3-related disease

   Robyn D. Moir, Emilio Merheb ... Ian M. Willis
5. 1. Biochemistry and Chemical Biology
   2. Evolutionary Biology

   Fitness landscape of substrate-adaptive mutations in evolved APC transporters

   Foteini Karapanagioti, Úlfur Á. Atlason ... Sebastian Obermaier
6. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   Rapid, DNA-induced interface swapping by DNA gyrase

   Thomas RM Germe, Natassja G Bush ... Anthony Maxwell

   DNA gyrase, a regulator of bacterial genomes topology, is shown to undergo rearrangements while functioning on DNA in vitro, with important potential consequences for gyrase-targeted antibiotics activity and bacterial evolution.
7. 1. Neuroscience

   Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival

   Jongkyun Kang, Guodong Huang ... Jie Shen

   LRRK plays an essential, cell-intrinsic role in the protection of dopaminergic neurons during aging, and new genetic findings suggest that LRRK2 mutations may impair its function, leading to dopaminergic neurodegeneration in PD.
8. 1. Biochemistry and Chemical Biology
   2. Structural Biology and Molecular Biophysics

   7,8-Dihydroxyflavone is a direct inhibitor of human and murine pyridoxal phosphatase

   Marian Brenner, Christoph Zink ... Antje Gohla

   Direct inhibition of pyridoxal phosphatase activity by 7,8-dihydroxyflavone indicates a pharmacological entry point into brain disorders associated with vitamin B6 deficiency.
9. 1. Computational and Systems Biology
   2. Neuroscience

   Deciphering the genetic code of neuronal type connectivity through bilinear modeling

   Mu Qiao

   A novel bilinear modeling approach reveals genetic code of neuronal connectivity, offering insights for targeted genetic interventions in neural circuits.
10. 1. Computational and Systems Biology
    2. Medicine

    Single-cell transcriptome analysis of cavernous tissues reveals the key roles of pericytes in diabetic erectile dysfunction

    Seo-Gyeong Bae, Guo Nan Yin ... Jihwan Park

    Single-cell RNA sequencing analysis of diabetic mouse cavernous tissue revealed that LBH is a novel pericyte marker and may interact with Crystallin Alpha B and Vimentin to promote neurovascular regeneration.