Influence of immunosuppressive drugs on natural killer cells in therapeutic drug exposure in liver transplantation

The study demonstrates that the cytolytic activity of NK cells in a mTORI including immunosuppression regimen is better preserved than with MMF and might support one potential explanation for a reduced recurrence rate of HCC after liver transplantation.

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A novel nomogram for prognosis stratification in salvage liver transplantation: a national-wide study with propensity score matching analysis in China

This study based on a huge data set from mainland China compared post-transplant survival of patients fulfilling Milan or Hangzhou criteria between SLT and PLT groups with propensity score matching analysis. Furthermore, we developed risk stratification system based on the nomogram to classify SLT recipients.

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A novel clinical model for risk prediction and stratification of new-onset diabetes mellitus after distal pancreatectomy

The incidence of new-onset diabetes after distal pancreatectomy remains high, particularly in patients with benign or low-grade malignant pancreatic lesions. The novel nomogram has satisfactory accuracy, reliability and utility in predicting post-pancreatectomy diabetes and may facilitate clinical decision-making by enhancing intervention and reducing unnecessary costs.

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Obesity and its influence on liver dysfunction, morbidity and mortality after liver resection

This large retrospective cohort study of 888 patients demonstrates that liver resections can safely be performed in obese patients. Postoperative complications and PHLF of 167 obese patients were comparable to normal weight and overweight patients.

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The Hong Kong consensus recommendations on the diagnosis and management of pancreatic cystic lesions

A group of Hong Kong experts has compiled recommendations for the management of pancreatic cystic lesions (PCL). Their recommendations cover diagnosis, stratification, and treatment of patients, including the use of pancreatic enzyme replacement therapy for those who develop pancreatic exocrine insufficiency

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An international Delphi consensus statement on metabolic dysfunction-associated fatty liver disease and risk of chronic kidney disease

Using a Delphi-based approach, a multidisciplinary panel of 50 international experts from 26 countries reached a consensus on epidemiology, mechanisms, management and treatment between MAFLD and CKD, to provide a framework for the development of appropriate guidance on CKD in individuals with MAFLD.

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Adipose tissue induces a better liver regeneration after living liver donation in normal weight donors

Regenerating liver hepatocytes normally accumulate fat microdroplets. The extrahepatic adipose tissue could be an important factor affecting liver regeneration after partial hepatectomy. In this study, we found that living donors with a higher fat mass index had a better liver volume gain after surgery.

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Comparative effectiveness of medical treatment vs. metabolic surgery for histologically proven non-alcoholic steatohepatitis and fibrosis: a matched network meta-analysis

Using a novel method for network meta-analysis, the effectiveness of surgical and non-surgical therapies including the newly developed drugs was compared. Surgery is more effective to resolve NASH compared to drug treatment and while both are equally effective regarding improvement of fibrosis.

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The influence of ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography on the N- and M-staging and subsequent clinical management of intrahepatic cholangiocarcinoma

PET/CT is superior to conventional imaging in diagnosing lymph node metastasis and distant metastasis, which improves the accuracy of tumor staging from 60.1% to 71.8%, and refines clinical management in 5.8% of ICC patients. PET/CT may bring survival benefits for ICC patients.

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Hepatobiliary Surgery and Nutrition (HBSN) is now a member of the Surgery Journal Editors Group (SJEG)

Beginning in September 2022, the Hepatobiliary Surgery and Nutrition (HBSN) adopted the Surgery Journal Editors Group (SJEG) joint statement and pledges to "strive for diversity in the peer review process and among the editorial boards and editorial leaders."

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Transcatheter arterial embolization-salvaged ALPPS, a novel ALPPS procedure especially for patients with hepatocellular carcinoma and severe fibrosis/cirrhosis

The ALPPS for HCC with fibrosis/cirrhosis is often associated with limited growth of future liver remnant (FLR). The new TAE-Salvaged ALPPS can induce significant FLR increase in patients with HCC and fibrosis/cirrhosis who fail to achieve sufficient FLR hypertrophy after conventional ALPPS stage-1.

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Prospective evaluation of 18F-FDG positron emission tomography in the preoperative staging of patients with hepatic colorectal metastases

A prospective, blinded study comparing utility of 18F-FDG-PET to CT and CT portography as was conducted as staging prior to resection of hepatic colorectal metastases. FDG-PET was found to be an important test, affecting treatment decisions in nearly one-third of patients.

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Peripancreatic vascular involvement in patients with type 1 autoimmune pancreatitis

This study revealed the real-world condition of peripancreatic vascular involvement (PVI) in patients with type 1 autoimmune pancreatitis (AIP) and described independent predictors of PVI development in AIP patients. The follow-up showed majority of PVI lesions achieved an improvement after corticosteroid treatment.

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Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma

We validate postoperative liver failure (PHLFS) and mortality risk scores (POMRS) after liver resection for perihilar cholangiocarcinoma, which was established by Western cohort, by Eastern cohort. This external validation study showed that for PHLFS the threshold for discrimination, but the POMRS were not applicable.

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CONGRATULATIONS to Yuman Fong, our senior editorial board member, also a friend of us, elected to National Academy of Medicine

Yuman Fong, M.D., the Sangiacomo Family Chair in Surgical Oncology at City of Hope, a world-renowned cancer research and treatment organization, was presented with one of the highest honors in health and medicine today.

The National Academy of Medicine (NAM) honored Fong “for transforming the fields of liver surgery, robotics in surgery, imaging and display in medicine, and gene therapy.” His contributions as a surgeon, engineer, innovator and mentor have yielded patents and first-in-human trials that translated scientific discoveries to medicines and medical devices.

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