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Effects of Benzo[a]pyrene Exposure on Human Hepatocellular Carcinoma Cell Angiogenesis, Metastasis, and NF-κB Signaling.
In: Environmental Health Perspectives, Jg. 123 (2015-03-01), Heft 3, S. 246-254
Online
academicJournal
Zugriff:
Background: Benzo[a]pyrene (B[a]P) is a common environmental and foodborne pollutant. Although the carcinogenicity of high-dose B[a]P has been extensively reported, the effects of longterm B[a]P exposure at lower environmental doses on cancer development are less understood. Objectives: We investigated the impact of B[a]P on human hepatocellular carcinoma (HCC) progression at various levels of exposure and identified a potential intervention target. Methods: We used a model based on human HCC cells exposed to various concentrations of B[a]P (i.e., 0.01, 1, or 100 nM) for 1 month to examine the effects of B[a]P on cell growth, migration, invasion, and angiogenicity. A bioluminescent murine model was established to assess tumor metastasis in vivo. Results: Chronic B[a]P exposure did not alter HCC cell growth but promoted cell migration and invasion both in vitro and in vivo. There was an negative association between B[a]P exposure and the survival of tumor-bearing mice. In addition, B[a]P-treated HCC cells recruited vascular endothelial cells and promoted tumor angiogenesis, possibly through elevating vascular endothelial growth factor secretion. Furthermore, the NF-κB pathway may be an adverse outcome pathway associated with the cumulative effects of B[a]P on HCC metastasis. Conclusions: These findings a) indicate that B[a]P has effects on HCC progression; b) identify a possible adverse outcome pathway; and c) contribute to a better understanding of the adverse effects of chronic exposure of B[a]P to human health. [ABSTRACT FROM AUTHOR]
Titel: |
Effects of Benzo[a]pyrene Exposure on Human Hepatocellular Carcinoma Cell Angiogenesis, Metastasis, and NF-κB Signaling.
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Autor/in / Beteiligte Person: | Ba, Qian ; Li, Junyang ; Huang, Chao ; Qiu, Hongling ; Li, Jingquan ; Chu, Ruiai ; Zhang, Wei ; Xie, Dong ; Wu, Yongning ; Wang, Hui |
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Zeitschrift: | Environmental Health Perspectives, Jg. 123 (2015-03-01), Heft 3, S. 246-254 |
Veröffentlichung: | 2015 |
Medientyp: | academicJournal |
ISSN: | 0091-6765 (print) |
DOI: | 10.1289/ehp.1408524 |
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