Urinary 1-Hydroxypyrene as a Biomarker of PAH Exposure in 3-Year-Old Ukrainian Children.
In: Environmental Health Perspectives, Jg. 114 (2006-04-01), Heft 4, S. 603-609
Online
academicJournal
Zugriff:
Urinary 1-hydroxypyrene (1-OHP) is a biomarker of polycyclic aromatic hydrocarbon (PAH) exposure. We measured urinary 1-OHP in 48 children 3 years of age in Mariupol, Ukraine, who lived near a steel mill and coking facility and compared these with 1-OHP concentrations measured in 42 children of the same age living in the capital city of Kiev, Ukraine. Children living in Mariupol had significantly higher urinary 1-OHP and creatinine-adjusted urinary 1-OHP than did children living in Kiev (adjusted: 0.69 vs. 0.34 µmol/mol creatinine, p < 0.001; unadjusted: 0.42 vs. 0.30 ng/mL, p = 0.002). Combined, children in both cities exposed to environmental tobacco smoke in their homes had higher 1-OHP than did children not exposed (0.61 vs. 0.42 µmol/mol creatinine; p = 0.04; p = 0.07 after adjusting for city). In addition, no significant differences were seen with sex of the children. Our sample of children in Mariupol has the highest reported mean urinary 1-OHP concentrations in children studied to date, most likely due to their proximity to a large industrial point source of PAHs. [ABSTRACT FROM AUTHOR]
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Urinary 1-Hydroxypyrene as a Biomarker of PAH Exposure in 3-Year-Old Ukrainian Children.
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Autor/in / Beteiligte Person: | Mucha, Amy Pelka ; Hryhorczuk, Daniel ; Serdyuk, Andrij ; Nakonechny, Joseph ; Zvinchuk, Alexander ; Erdal, Serap ; Caudill, Motria ; Scheff, Peter ; Lukyanova, Elena ; Shkiryak-Nyzhnyk, Zoreslava ; Chislovska, Natalia |
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Zeitschrift: | Environmental Health Perspectives, Jg. 114 (2006-04-01), Heft 4, S. 603-609 |
Veröffentlichung: | 2006 |
Medientyp: | academicJournal |
ISSN: | 0091-6765 (print) |
DOI: | 10.1289/ehp.7898 |
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