Early Kidney Damage in a Population Exposed to Cadmium and Other Heavy Metals.
In: Environmental Health Perspectives, Jg. 117 (2009-02-01), Heft 2, S. 181-184
Online
academicJournal
Zugriff:
BACKGROUND: Exposure to heavy metals may cause kidney damage. The population living near the Avonmouth zinc smelter has been exposed to cadmium and other heavy metals for many decades. OBJECTIVES: We aimed to assess Cd body burden and early signs of kidney damage in the Avonmouth population. METHODS: We used dispersion modeling to assess exposure to Cd. We analyzed urine samples from the local population (n = 180) for Cd (U-Cd) to assess dose (body burden) and for three biomarkers of early kidney damage [N-acetyl-β-D-glucosaminidase (U-NAG), retinol-binding protein, and α-1-microglobulin]. We collected information on occupation, intake of homegrown vegetables, smoking, and medical history by questionnaire. RESULTS: Median U-Cd concentrations were 0.22 nmol/mmol creatinine (nonsmoking 0.18/smoking 0.40) and 0.34 nmol/mmol creatinine (nonsmoking 0.31/smoking 0.46) in non-occupationally exposed men and women, respectively. There was a significant dose--response relationship between U-Cd and the prevalence of early renal damage--defined as U-NAG > 0.22 IU/mmol--with odds ratios of 2.64 [95% confidence interval (95% CI), 0.70--9.97] and 3.64 (95% CI, 0.98--13.5) for U-Cd levels of 0.3 to < 0.5 and levels ≥ 0.5 nmol/mmol creatinine, respectively (p for trend = 0.045). CONCLUSION: U-Cd concentrations were close to levels where kidney and bone effects have been found in other populations. The dose--response relationship between U-Cd levels and prevalence of U-NAG above the reference value support the need for measures to reduce environmental Cd exposure. [ABSTRACT FROM AUTHOR]
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Early Kidney Damage in a Population Exposed to Cadmium and Other Heavy Metals.
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Autor/in / Beteiligte Person: | Thomas, Laura D. K. ; Hodgson, Susan ; Nieuwenhuijsen, Mark ; Jarup, Lars |
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Zeitschrift: | Environmental Health Perspectives, Jg. 117 (2009-02-01), Heft 2, S. 181-184 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0091-6765 (print) |
DOI: | 10.1289/ehp.11641 |
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