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Prenatal Lead Levels, Plasma Amyloid β Levels, and Gene Expression in Young Adulthood.
In: Environmental Health Perspectives, Jg. 120 (2012-05-01), Heft 5, S. 702-707
Online
academicJournal
Zugriff:
Background: Animal studies suggest that early-life lead exposure influences gene expression and production of proteins associated with Alzheimerfs disease (AD). Objectives: We attempted to assess the relationship between early-life lead exposure and potential biomarkers for AD among young men and women. We also attempted to assess whether early-life lead exposure was associated with changes in expression of AD-related genes. Methods: We used sandwich enzyme-linked immunosorbent assays (ELISA) to measure plasma concentrations of amyloid β proteins Aβ40 and Aβ42 among 55 adults who had participated as newborns and young children in a prospective cohort study of the effects of lead exposure on development. We used RNA microarray techniques to analyze gene expression. Results: Mean plasma Aβ42 concentrations were lower among 13 participants with high umbilical cord blood lead concentrations (≥ 10 µg/dL) than in 42 participants with lower cord blood lead concentrations (p = 0.08). Among 10 participants with high prenatal lead exposure, we found evidence of an inverse relationship between umbilical cord lead concentration and expression of ADAM metallopeptidase domain 9 (ADAM9), reticulon 4 (RTN4), and low-density lipoprotein receptor-related protein associated protein 1 (LRPAP1) genes, whose products are believed to affect Aβ production and deposition. Gene network analysis suggested enrichment in gene sets involved in nerve growth and general cell development. Conclusions: Data from our exploratory study suggest that prenatal lead exposure may influence Aβ-related biological pathways that have been implicated in AD onset. Gene network analysis identified further candidates to study the mechanisms of developmental lead neurotoxicity. [ABSTRACT FROM AUTHOR]
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Prenatal Lead Levels, Plasma Amyloid β Levels, and Gene Expression in Young Adulthood.
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Autor/in / Beteiligte Person: | Mazumdar, Maitreyi ; Xia, Weiming ; Hofmann, Oliver ; Gregas, Matthew ; Sui, Shannan Ho ; Hide, Winston ; Yang, Ting ; Needleman, Herbert L. ; Bellinger, David C. |
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Zeitschrift: | Environmental Health Perspectives, Jg. 120 (2012-05-01), Heft 5, S. 702-707 |
Veröffentlichung: | 2012 |
Medientyp: | academicJournal |
ISSN: | 0091-6765 (print) |
DOI: | 10.1289/ehp.1104474 |
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