HBeAg阴性慢性乙型肝炎获得HBsAg清除 与血清白细胞介素17水平的关系.

Objective To investigate the association between HBsAg clearance and serum level of interleukin -17 (IL-17 ) in HBeAg -negative chronic hepatitis B (CHB) patients treated by pegylated interferon (PEG - IFN) . Methods A total of 13 HBeAg - negative CHB patients who visited Beijing YouAn Hospital from January 2012 to January 2015 were enrolled. After the 24 - week treatment with PEG -IFN, 6 achieved HBsAg clearance (R group) and 7 did not achieve HBsAg clearance (NR group). The Luminex technology was used to measure the serum level of IL - 17 at baseline and weeks 12 and 24 of treatment. Ten healthy controls and 6 patients with acute hepatitis B ( AHB) were enrolled and serum level of IL - 17 was measured. An analysis of variance was used for comparison of continuous data between multiple groups, and the SNK - q test was used for further pairwise comparison; the t - test was used for comparison of continuous data between any two groups; the chi - square test was used for comparison of categorical data between groups. Results The AHB group had the highest serum level of IL - 17 at baseline, followed by the CHB group and healthy control group, and the serum level of IL - 17 at baseline showed significant differences between the three groups (P <0. 05) . After the PEG - IFN treatment for 24 weeks, HBeAg - negative CHB patients showed a significant reduction in serum level ofIL-17(P = 0. 044). R group had a significantly higher serum level of IL - 17 than NR group and showed a significant reduction in the serum level of IL - 17 after PEG - IFN treatment, while NR group showed no significant increase or reduction in the serum level of IL - 17. Conclusion In the PEG - IFN treatment for HBeAg - negative CHB patients, a high serum level of IL - 17 at baseline and a significant reduction in serum level of IL - 17 helps with HBsAg clearance. [ABSTRACT FROM AUTHOR]

目的　探讨聚乙二醇干扰素（ＰＥＧ － ＩＦＮ）治疗ＨＢｅＡｇ 阴性慢性乙型肝炎（ＣＨＢ）发生ＨＢｓＡｇ 清除与血清白细胞介素（ＩＬ） １７ 水平的关系。方法　选择２０１２ 年１ 月－２０１５ 年１ 月于北京佑安医院就诊的ＨＢｅＡｇ 阴性ＣＨＢ 患者１３ 例，经ＰＥＧ － ＩＦＮ 治疗２４ 周，其中６ 例获得ＨＢｓＡｇ 清除（Ｒ 组），７ 例未获得ＨＢｓＡｇ 清除（ＮＲ 组）。用Ｌｕｍｉｎｅｘ 技术检测患者基线、治疗１２ 周和２４ 周血清ＩＬ －１７ 水平。同时检测１０ 例健康人和６ 例急性乙型肝炎（ＡＨＢ）患者发病时的血清ＩＬ － １７ 水平。计量资料两组间比较采用ｔ 检验， 多组间比较采用方差分析，进一步两两比较采用ＳＮＫ － ｑ 检验；计数资料组间比较采用χ２ 检验。结果　ＡＨＢ 组基线血清ＩＬ － １７ 水 平最高，其次是ＣＨＢ 组，健康对照组最低，３ 组间比较差异有统计学意义（Ｐ ＜ ０． ０５）。ＣＨＢ 患者经ＰＥＧ － ＩＦＮ 治疗２４ 周后，ＩＬ － １７ 水平较基线明显下降（Ｐ ＝０ ０４４）。Ｒ 组基线血清ＩＬ －１７ 水平高于ＮＲ 组，而且在ＰＥＧ － ＩＦＮ 治疗后明显下降；而ＮＲ 组ＩＬ － １７ 升 高或降低不明显。结论　ＰＥＧ － ＩＦＮ 治疗ＨＢｅＡｇ 阴性ＣＨＢ 患者，ＩＬ － １７ 基线高水平和治疗过程中明显降低可能有利于ＨＢｓＡｇ 清 除。 [ABSTRACT FROM AUTHOR]