Interleukin 17A and Toll-like Receptor 4 in Patients with Arterial Hypertension.
In: Kidney & Blood Pressure Research, Jg. 42 (2017-05-01), Heft 1, S. 99-108
academicJournal
Zugriff:
Background/Aims: Immune responses are involved in arterial hypertension. An observational cross-sectional case control study was conducted to estimate the association between Toll-like receptor 4 (TLR4) expression and interleukin (IL)-17A serum levels in patients with controlled and non-controlled hypertension. Methods: We have enrolled 105 non-complicated otherwise healthy hypertensive patients: 53 with well-controlled blood pressure and 52 noncontrolled. TLR4 peripheral monocytes expression and serum IL-17A levels were determined by flow cytometry and ELISA, respectively. Results: Non-controlled patients exhibited higher TLR4 expression than well-controlled (25.60 vs. 21.99, P=0.011). TLR4 expression was lower in well-controlled patients who were prescribed beta blockers (18.9 vs. 22.6, P=0.005) and IL-17A concentration was higher in patients using diuretics in either group (1.41 vs. 2.01 pg/ ml, P<0.001; well-controlled 1.3 vs. 1.8 pg/ml, P= 0.023; non-controlled 1.6 vs. 2.3 pg/ml, P=0.001). Correlation between IL-17A concentration and hypertension duration was observed in non-controlled patients (Spearman correlation coefficient. ρ=0.566, P<0.001) whereas in well-controlled patients a correlation was found between hypertension duration and TLR4 expression (ρ=0.322, P=0.020). Conclusions: Arterial hypertension stimulates the immune response regardless of blood pressure regulation status. Prolonged hypertension influences peripheral monocyte TLR4 expression and IL-17A serum levels. Anti-hypertensive drugs have different immunomodulatory effects: diuretics are associated with higher IL-17A concentration and beta-blockers with lower TLR4 expression. [ABSTRACT FROM AUTHOR]
Titel: |
Interleukin 17A and Toll-like Receptor 4 in Patients with Arterial Hypertension.
|
---|---|
Autor/in / Beteiligte Person: | Simundic, Tihana ; Jelakovic, Bojan ; Dzumhur, Andrea ; Turk, Tajana ; Sahinovic, Ines ; Dobrosevic, Blazenka ; Takac, Boris ; Barbic, Jerko |
Zeitschrift: | Kidney & Blood Pressure Research, Jg. 42 (2017-05-01), Heft 1, S. 99-108 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 1420-4096 (print) |
DOI: | 10.1159/000471900 |
Schlagwort: |
|
Sonstiges: |
|