Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene.
In: Clinical Case Reports, Jg. 5 (2017-08-01), Heft 8, S. 1218-1221
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academicJournal
Zugriff:
Key Clinical Message This manuscript describes the case of a patient with sickle cell anemia who died of fulminant hepatitis after therapy with the iron chelator Deferasirox. The patient was homozygous for the −1774delG polymorphism in the Abcc2 gene, which raises the concern about the use of hepatotoxic drugs in this specific context. [ABSTRACT FROM AUTHOR]
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Deferasirox associated with liver failure and death in a sickle cell anemia patient homozygous for the −1774delG polymorphism in the Abcc2 gene.
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Autor/in / Beteiligte Person: | Braga, Caroline C. B. ; Benites, Bruno Deltreggia ; Albuquerque, Dulcineia M. ; Alvarez, Marisa C. ; Seva‐Pereira, Tiago ; Duarte, Bruno K. L. ; Costa, Fernando F. ; Gilli, Simone C. O. ; Saad, Sara T. O. |
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Zeitschrift: | Clinical Case Reports, Jg. 5 (2017-08-01), Heft 8, S. 1218-1221 |
Veröffentlichung: | 2017 |
Medientyp: | academicJournal |
ISSN: | 2050-0904 (print) |
DOI: | 10.1002/ccr3.1040 |
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