Development and validation of Women Acute Myocardial Infarction in-Hospital Mortality Score (WAMI Score).
In: International Journal of Cardiology, Jg. 259 (2018-05-15), S. 31-39
academicJournal
Zugriff:
Background A variety of risk models have been developed to predict acute myocardial infarction (AMI) in-hospital mortality risk. As a distinct, higher-risk population, women with AMI have different risk profiles from their men counterparts. Published researches have indicated that the interaction between variables in these models for in-hospital mortality and gender are significant. Due to the interaction and gender differences, the predicting value of these risk models for women could be controversial. Methods Databases from the China Patient-centered Evaluative Assessment of Cardiac Events (China PEACE) Retrospective AMI Study were utilized for model derivation ( n = 16,100, women were 4896) and databases from the China PEACE Prospective AMI Study for model validation ( n = 6207, women were 2090). A multivariable backward stepwise logistic regression was used to examine correlates of in-hospital mortality, and the variables were subsequently weighted and integrated into a scoring system. Results We constructed a novel risk-predicting tool to estimate the baseline risk of in-hospital mortality among women with AMI. The risk score includes 8 variables [age, systolic blood pressure, heart rate, initial glomerular filtration rate (GFR), serum glucose, Killip class, cardiac arrest, ventricular tachycardia/ventricular fibrillation (VT/VF)]. The prognostic discriminatory capacity of the Women Acute Myocardial Infarction in-Hospital Mortality (WAMI) risk score was excellent (c statistic 0.84, 95% confidence interval [CI]: 0.83 to 0.86, p < 0.001). External validation of the model showed better prognostic capacity (c statistic 0.87, 95% CI: 0.84 to 0.90, p < 0.001) than the GRACE risk score (0.77, 95% CI 0.72–0.82, p < 0.001) and TIMI risk score (0.72, 95% CI 0.68–0.77, p < 0.001). Conclusions The WAMI Score is a simple robust tool for predicting the in-hospital mortality risk of women with AMI. Trial registration “China PEACE-Retrospective AMI Study”, NCT01624883, retrospectively registered: April 2012. Date of enrolment of the first participant to the trial: June 17, 2012. “China PEACE-Prospective AMI Study”, NCT01624909, prospectively registered: December 2012. Date of enrolment of the first participant to the trial: June 17, 2012. [ABSTRACT FROM AUTHOR]
Titel: |
Development and validation of Women Acute Myocardial Infarction in-Hospital Mortality Score (WAMI Score).
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Autor/in / Beteiligte Person: | Qi, Yu ; Wang, Wenyao ; Zhang, Kuo ; An, Shimin ; Wang, Siyuan ; Zheng, Jilin ; Tang, Yi-Da |
Zeitschrift: | International Journal of Cardiology, Jg. 259 (2018-05-15), S. 31-39 |
Veröffentlichung: | 2018 |
Medientyp: | academicJournal |
ISSN: | 0167-5273 (print) |
DOI: | 10.1016/j.ijcard.2017.12.010 |
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