National and regional hospitalization rates for allergic disorders in the United States: A 17‐year time‐trend analysis.

Keywords: allergy diagnosis; anaphylaxis; angioedema; asthma; epidemiology; urticaria EN allergy diagnosis anaphylaxis angioedema asthma epidemiology urticaria 1243 1247 5 05/20/20 20200501 NES 200501 To the Editor, Allergic disorders are common and responsible for considerable morbidity, impairment in quality of life, healthcare utilization, and both direct and indirect healthcare costs.[1] For example, asthma in the United States affects an estimated of 26 million Americans, the medical expenditure is up to $4423 greater for those with markers of uncontrolled asthma together with a greater healthcare utilization and decreased productivity.[2] High costs are also related to patients with anaphylaxis,[3] urticaria,[4] atopic eczema/dermatitis,[5] and allergic rhinitis.[6] Studies analyzing such national trends were performed for countries such as Poland,[7] UK,[8] and Spain.[9] For example, in the UK, Gupta et al[8] analyzed trends in the prevalence, morbidity, and mortality for allergic disorders, excluding asthma, based on hospital admission and mortality data. Increases in hospitalization rates at national levels (Figure A) were observed for a primary diagnosis of anaphylaxis (APC 2.1%, CI: 0.1, 4.2) and angioedema (APC 3.3%, CI: 1.8, 4.8). Allergy diagnosis, anaphylaxis, angioedema, asthma, epidemiology, urticaria. [Extracted from the article]