New loss of smell and taste: Uncommon symptoms in COVID-19 patients on Nord Franche-Comte cluster, France.
In: International Journal of Infectious Diseases, Jg. 100 (2020-11-01), S. 117-122
Online
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Zugriff:
• New loss of taste or smell was not included as common symptoms of COVID-19 until March 2020 when the pandemic started in Western countries. • It is interesting to know the prevalence of such symptoms and how they were related to disease severity and prognosis. • In our study including 70 patients, anosmia and dysgeusia were present in half of COVID-19 patients. • The mean duration of anosmia was 7 days and the outcome seems favorable in less than 28 days. New loss of smell or taste was not included as common symptoms of COVID-19 until March 2020 when the pandemic started in Western countries. We want to describe the prevalence and features of anosmia and dysgeusia in COVID-19 patients. We retrospectively investigated the clinical features of confirmed cases of COVID-19 in Nord Franche-Comté Hospital, Trevenans, France, between March, 1st and March, 14th 2020. We used SARS-CoV-2 real time RT-PCR in respiratory samples to confirm the cases. Of 70 patient enrolled, the mean age was 57.0 years and 29 patients (41%) were men. Median Charlson comorbidity index was 1.70(±2.5). Twenty-seven (39%) patients had pneumonia. Fatigue (93% [65]), cough (80% [55]) and fever (77% [54]) were the three main symptoms. Neurologic symptoms were present in more than half of the patients: anosmia (53% [37]) and dysgeusia (48% [34]). The mean duration of anosmia was 7.4 (±5, [1–21]) days, 51% (36/70) recovered before 28 days of evolution. Only one patient with anosmia had not recovered at the end of the follow-up. Patients with anosmia had less often a pneumonia (10/37 vs 17/33, p = 0.036), were less often hospitalized (13/37 vs 20/33, p = 0.033) and needed less often oxygen therapy (6/37 vs 17/33, p = 0.002) than patients without anosmia. There were no statistically differences for viral load between patients with anosmia and patients without anosmia (5.5 [2.0–8.6] vs 5.3 [2.1–8.5] log copies/ml respectively, p = 0.670). The fatality of COVID-19 in our study was 6% with four deaths. Anosmia and dysgeusia are present in half of COVID-19 patients. The mean duration of anosmia was 7 days and the outcome seems favorable in less than 28 days. [ABSTRACT FROM AUTHOR]
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New loss of smell and taste: Uncommon symptoms in COVID-19 patients on Nord Franche-Comte cluster, France.
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Autor/in / Beteiligte Person: | Klopfenstein, Timothée ; Zahra, Hajer ; Kadiane-Oussou, N'dri Juliette ; Lepiller, Quentin ; Royer, Pierre-Yves ; Toko, Lynda ; Gendrin, Vincent ; Zayet, Souheil |
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Zeitschrift: | International Journal of Infectious Diseases, Jg. 100 (2020-11-01), S. 117-122 |
Veröffentlichung: | 2020 |
Medientyp: | academicJournal |
ISSN: | 1201-9712 (print) |
DOI: | 10.1016/j.ijid.2020.08.012 |
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