The relation between VLDL-cholesterol and risk of cardiovascular events in patients with manifest cardiovascular disease.
In: International Journal of Cardiology, Jg. 322 (2021), S. 251-257
academicJournal
Zugriff:
Apolipoprotein B containing lipoproteins are atherogenic. There is evidence that with low plasma low density lipoprotein cholesterol (LDL-C) levels residual vascular risk might be caused by triglyceride rich lipoproteins such as very-low density lipoproteins (VLDL), chylomicrons and their remnants. We investigated the relationship between VLDL-cholesterol (VLDL-C) and recurrent major adverse cardiovascular events (MACE), major adverse limb events (MALE) and all-cause mortality in a cohort of patients with cardiovascular disease. Prospective cohort study in 8057 patients with cardiovascular disease from the UCC-SMART study. The relation between calculated VLDL-C levels and the occurrence of MACE, MALE and all-cause mortality was analyzed with Cox regression models. Patients mean age was 60 ± 10 years, 74% were male, 4894 (61%) had coronary artery disease, 2445 (30%) stroke, 1425 (18%) peripheral arterial disease and 684 (8%) patients had an abdominal aorta aneurysm at baseline. A total of 1535 MACE, 571 MALE and 1792 deaths were observed during a median follow up of 8.2 years (interquartile range 4.512.2). VLDL-C was not associated with risk of MACE or all-cause mortality. In the highest quartile of VLDL-C the risk was higher for major adverse limb events (MALE) (HR 1.49; 95%CI 1.16–1.93) compared to the lowest quartile, after adjustment for confounders including LDL-C and lipid lowering medication. In patients with clinically manifest cardiovascular disease plasma VLDL-C confers an increased risk for MALE, but not for MACE and all-cause mortality, independent of established risk factors including LDL-C and lipid-lowering medication. • In patients with vascular disease VLDL-C levels are associated with MALE. • This risk is independent of conventional risk factors including LDL-C levels and use of lipid-lowering therapy. • Especially in patients with CAD, there is a relationship with VLDL-C and MACE, MALE and MI. • VLDL-C could attribute to the residual CV risk in patients with vascular disease. [ABSTRACT FROM AUTHOR]
Titel: |
The relation between VLDL-cholesterol and risk of cardiovascular events in patients with manifest cardiovascular disease.
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Autor/in / Beteiligte Person: | Heidemann, Britt E. ; Koopal, Charlotte ; Bots, Michiel L. ; Asselbergs, Folkert W. ; Westerink, Jan ; Visseren, Frank L.J. |
Zeitschrift: | International Journal of Cardiology, Jg. 322 (2021), S. 251-257 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 0167-5273 (print) |
DOI: | 10.1016/j.ijcard.2020.08.030 |
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