Identification and Verification of a 17 Immune-Related Gene Pair Prognostic Signature for Colon Cancer.
In: BioMed Research International, 2021-05-24, S. 1-8
Online
academicJournal
Zugriff:
Background. Colon cancer (CC) is a malignant tumor with a high incidence and poor prognosis. Accumulating evidence shows that the immune signature plays an important role in the tumorigenesis, progression, and prognosis of CC. Our study is aimed at establishing a novel robust immune-related gene pair signature for predicting the prognosis of CC. Methods. Gene expression profiles and corresponding clinical information are obtained from two public data sets: The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO, GSE39582). We screened out immune-related gene pairs (IRGPs) associated with prognosis in the discovery cohort. Lasso-Cox proportional hazard regression was used to develop the best prognostic signature model. According to this, the patients in the validation cohort were divided into high immune-risk group and low immune-risk group, and the prediction ability of the signature model was verified by survival analysis and independent prognostic analysis. Results. A total of 17 IRGPs composed of 26 IRGs were used to construct a prognostic-related risk scoring model. This model accurately predicted the prognosis of CC patients, and the patients in the high immune-risk group indicated poor prognosis in the discovery cohort and validation cohort. Besides, whether in univariate or multivariate analysis, the IRGP signature was an independent prognostic factor. T cell CD4 memory resting in the low-risk group was significantly higher than that in the high-risk group. Functional analysis showed that the biological processes of the low-risk group included "TCA cycle" and "RNA degradation," while the high-risk group was enriched in the "CAMs" and "focal adhesion" pathways. Conclusion. We have successfully established a signature model composed of 17 IRGPs, which provides a novel idea to predict the prognosis of CC patients. [ABSTRACT FROM AUTHOR]
Titel: |
Identification and Verification of a 17 Immune-Related Gene Pair Prognostic Signature for Colon Cancer.
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Autor/in / Beteiligte Person: | Zhang, Qianshi ; Feng, Zhen ; Zhang, Yongnian ; Shi, Shasha ; Zhang, Yu ; Ren, Shuangyi |
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Zeitschrift: | BioMed Research International, 2021-05-24, S. 1-8 |
Veröffentlichung: | 2021 |
Medientyp: | academicJournal |
ISSN: | 2314-6133 (print) |
DOI: | 10.1155/2021/6057948 |
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