Serum Vitamin D Status in Older Adults: A Cohort Study.
In: Iranian Journal of Medical Sciences, Jg. 48 (2023-05-01), Heft 3, S. 277-285
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Zugriff:
Background: Vitamin D is best known as a key regulator of bone metabolism and calcium and phosphate homeostasis. This study aimed to assess the effect of different factors on the five-year changes in serum vitamin D concentration among older adults. Methods: This cohort study was conducted on adults aged ≥60 years living in Amirkola, in the North of Iran, from 2012 to 2017. Serum 25-hydroxyvitamin D (25-OH vitamin D) concentrations of <20, 20-29.99, and ≥30 ng/mL, respectively, were used to designate vitamin D deficiency, insufficiency, and sufficiency. Any variation between the second and baseline values of the 25-OH vitamin D concentration was reported as a five-year difference. Data were analyzed using SPSS version 17.0, and Chi square, t test, one-way ANOVA, and Tukey HSD post hoc tests were employed. P values less than 0.05 were considered statistically significant. Results: The mean serum concentration of 25-OH vitamin D at baseline and follow-up examination in 1011 individuals was 34.68±33.18 and 23.88±14.91, respectively (P<0.001). Following a five-year follow-up, vitamin D deficiency, insufficiency, and sufficiency were found in 452 (44.7%), 334 (33.0%), and 225 (22.3%) cases, respectively. The reduction in serum 25-OH vitamin D concentration after five years was significantly influenced by the administration of vitamin D (P=0.013) and calcium (P=0.007) supplements, serum profile of parathyroid hormone (PTH) (P=0.010), calcium (P=0.021), and phosphorous (P=0.021). However, age, sex, body mass index, metabolic syndrome, and physical activity had no significant impact (P>0.05). Conclusion: Regardless of age, sex, body mass index, metabolic syndrome, or physical activity, the mean serum concentration of vitamin D decreased over a five-year follow-up. [ABSTRACT FROM AUTHOR]
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Serum Vitamin D Status in Older Adults: A Cohort Study.
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Autor/in / Beteiligte Person: | Mouodi, Simin ; Delbari, Sajedeh ; Hosseini, Seyed Reza ; Ghadimi, Reza ; Bijani, Ali |
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Zeitschrift: | Iranian Journal of Medical Sciences, Jg. 48 (2023-05-01), Heft 3, S. 277-285 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 0253-0716 (print) |
DOI: | 10.30476/IJMS.2022.94269.2550 |
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