血清 CCL17、CXCR4 与重度子痫前期患者 Th17 细胞的相关性分析 及对母婴结局的影响.
In: Progress in Modern Biomedicine, Jg. 23 (2023-04-01), Heft 7, S. 1304-1308
academicJournal
Zugriff:
To investigate the correlation analysis of serum C-C chemokine ligand 17 (CCL17), CXC chemokine receptor 4 (CXCR4) and helper T cell (Th) 17 in patients with severe pre-eclampsia (SPE) and their effects on maternal and infant outcomes. 169 patients with SPE (SPE group) and 77 healthy pregnant women (control group) who were admitted to the Obstetrics and Gynecology Department of the Second Affiliated Hospital of Soochow University from March 2018 to March 2021 were selected. The serum CCL 17 and CXCR4 levels as well as peripheral blood Th17 cell and their cytokines were detected, and the maternal and infant outcomes were analyzed. The relationship between serum CCL 17 and CXCR4 levels and peripheral blood Th17 cell and their cytokines were analyzed by Pearson, and multivariate Logistic regression was used to analyze the related factors of poor maternal and infant outcomes of SPE. The serum CCL17 and CXCR4 levels in the SPE group were lower than those in the control group (P<0.05), and the proportion of peripheral blood Th17 cell and the serum interleukin (IL) -17 level were higher than those in the control group(P<0.05). Serum CCL17 and CXCR4 levels were negatively correlated with the proportion of peripheral blood Th17 cell and serum IL-17 level (P<0.05). There were 53 cases with poor maternal and infant outcomes, and 116 cases with good maternal and infant outcomes. The CCL 17 and CXCR4 levels in the poor maternal and infant outcome group were lower than those in the good maternal and infant outcome group(P<0.05). High proportion of Th17 cell, old age, low CCL17 and CXCR4 level were risk factors for adverse maternal and infant outcomes in patients with SPE (P<0.05). The serum CCL17 and CXCR4 levels in patients with SPE are decreased, which are associated with increased proportion of peripheral blood Th17 cell, increased serum IL-17 level, and adverse maternal and infant outcomes. Low levels of CCL17 and CXCR4 are risk factors for adverse maternal and infant outcomes in patients with SPE. [ABSTRACT FROM AUTHOR]
目的:探讨血清 C-C 基序趋化因子配体 17(CCL17)、CXC 趋化因子受体 4(CXCR4)与重度子痫前期(SPE)患者辅助性 T 细 胞(Th)17 细胞的相关性分析及对母婴结局的影响。方法:选择 2018 年 3 月至 2021 年 3 月苏州大学附属第二医院妇产科收治的 169 例 SPE 患者(SPE 组)和 77 例健康孕产妇(对照组)。检测血清 CCL 17、CXCR4 水平和外周血 Th17 细胞及其细胞因子。 Pearson 分析血清 CCL 17、CXCR4 水平与外周血 Th17 细胞及其细胞因子的关系,多因素 Logistic 回归分析 SPE 母婴结局不良的 相关因素。结果:SPE 组血清 CCL17、CXCR4 水平低于对照组(P<0.05),外周血 Th17 细胞占比、血清白细胞介素(IL)-17 水平高 于对照组(P<0.05)。血清 CCL17、CXCR4 水平与外周血 Th17 细胞占比、血清 IL-17 水平呈负相关(P<0.05)。母婴结局不良 53 例,母婴结局良好 116 例,母婴结局不良组血清 CCL 17、CXCR4 水平低于母婴结局良好组(P<0.05)。高 Th17 细胞占比、年龄大、 低水平 CCL17、CXCR4 是 SPE 患者母婴结局不良的危险因素(P<0.05)。结论:SPE 患者血清 CCL17、CXCR4 水平降低,且与外 周血 Th17 细胞占比增加,血清 IL-17 水平增高有关,低水平 CCL17、CXCR4 是 SPE 患者母婴结局不良的危险因素。 [ABSTRACT FROM AUTHOR]
Titel: |
血清 CCL17、CXCR4 与重度子痫前期患者 Th17 细胞的相关性分析 及对母婴结局的影响.
|
---|---|
Autor/in / Beteiligte Person: | 孙白云 ; 瑶, 蒋 ; 荣, 张 ; 贾素红 ; 莉, 凌 |
Zeitschrift: | Progress in Modern Biomedicine, Jg. 23 (2023-04-01), Heft 7, S. 1304-1308 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1673-6273 (print) |
DOI: | 10.13241/j.cnki.pmb.2023.07.020 |
Schlagwort: |
|
Sonstiges: |
|