Procalcitonin-Guided Antibiotic Prescription in Patients With COVID-19: A Multicenter Observational Cohort Study.
In: CHEST, Jg. 164 (2023-09-01), Heft 3, S. 596-605
academicJournal
Zugriff:
Despite the low rate of bacterial coinfection, antibiotics are very commonly prescribed in hospitalized patients with COVID-19. Does the use of a procalcitonin (PCT)-guided antibiotic protocol safely reduce the use of antibiotics in patients with a COVID-19 infection? In this multicenter cohort, three groups of patients with COVID-19 were compared in terms of antibiotic consumption, namely one group treated based on a PCT-algorithm in one hospital (n = 216) and two control groups, consisting of patients from the same hospital (n = 57) and of patients from three similar hospitals (n = 486) without PCT measurements during the same period. The primary end point was antibiotic prescription in the first week of admission. Antibiotic prescription during the first 7 days was 26.8% in the PCT group, 43.9% in the non-PCT group in the same hospital, and 44.7% in the non-PCT group in other hospitals. Patients in the PCT group had lower odds of receiving antibiotics in the first 7 days of admission (OR, 0.33; 95% CI, 0.16-0.66 compared with the same hospital; OR, 0.42; 95% CI, 0.28-0.62 compared with the other hospitals). The proportion of patients receiving antibiotic prescription during the total admission was 35.2%, 43.9%, and 54.5%, respectively. The PCT group had lower odds of receiving antibiotics during the total admission only when compared with the other hospitals (OR, 0.23; 95% CI, 0.08-0.63). There were no significant differences in other secondary end points, except for readmission in the PCT group vs the other hospitals group. PCT-guided antibiotic prescription reduces antibiotic prescription rates in hospitalized patients with COVID-19, without major safety concerns. [Display omitted] [ABSTRACT FROM AUTHOR]
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Procalcitonin-Guided Antibiotic Prescription in Patients With COVID-19: A Multicenter Observational Cohort Study.
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Autor/in / Beteiligte Person: | Hessels, Lisa M. ; Speksnijder, Esther ; Paternotte, Nienke ; van Huisstede, Astrid ; Thijs, Willemien ; Scheer, Margot ; van der Steen-Dieperink, Mariëlle ; Knarren, Lieve ; van Den Bergh, Joop P. ; Winckers, Kristien ; Henry, Ronald ; Simsek, Suat ; Boersma, Wim G. |
Zeitschrift: | CHEST, Jg. 164 (2023-09-01), Heft 3, S. 596-605 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 0012-3692 (print) |
DOI: | 10.1016/j.chest.2023.04.032 |
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