Evaluation of syringin's neuroprotective effect in a model of neonatal hypoxic-ischemic brain injury.
In: Turkish Journal of Medical Sciences, Jg. 53 (2023-09-01), Heft 5, S. 1312-1320
Online
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Zugriff:
Background/aim: A significant cause of mortality and morbidity in the neonatal era is hypoxic-ischemic encephalopathy (HIE). This study examined the histopathological analysis and neuroprotective impact of syringin (SYR) in an experimental HIE rat model. Material and methods: On the 7th postnatal day, 24 Wistar albino rats were evaluated in 3 groups using the HIE model under gas anesthesia. In the experiment, Group A received 10 mg/kg SYR plus dimethyl sulfoxide (DMSO), Group B received DMSO only, and Group C served as a sham group. Immunohistochemical techniques were used to assess apoptotic cell measurement and proinflammatory cytokines (TNF-a and IL-1ß primary antibodies). Results: Rats suffering from hypoxic-ischemic brain damage had their apoptosis assessed. The SYR and sham groups had statistically fewer cells undergoing apoptosis (p < 0.001). There was no difference between the groups in terms of IL-1ß and TNF-a during immunohistochemical staining. Neuronal degeneration was significantly lower in the histological evaluation of the hippocampus in the SYR group (p = 0.01). A statistically significant difference (p = 0.01) was observed between the SYR and the control groups regarding pericellular and perivascular edema. Conclusion: SYR reduced apoptosis, perivascular and pericellular edema, and neuronal degeneration in rat cerebral tissue. These results raise the possibility that SYR may have a neuroprotective effect on the harm brought on by HIE. This is the first investigation of SYR's function within the HIE paradigm. [ABSTRACT FROM AUTHOR]
Titel: |
Evaluation of syringin's neuroprotective effect in a model of neonatal hypoxic-ischemic brain injury.
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Autor/in / Beteiligte Person: | ERGON, Ezgi Yangın ; ÇELİK, Aslı ; DİNİZ, Gülden ; ÇOLAK, Rüya ; ÖZDEMİR, Senem Alkan ; ÇALKAVUR, Şebnem ; YILMAZ, Osman |
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Zeitschrift: | Turkish Journal of Medical Sciences, Jg. 53 (2023-09-01), Heft 5, S. 1312-1320 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1300-0144 (print) |
DOI: | 10.55730/1300-0144.5697 |
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