Comparative Analysis of Morphological and Functional Effects of 225 Ac- and 177 Lu-PSMA Radioligand Therapies (RLTs) on Salivary Glands.
In: International Journal of Molecular Sciences, Jg. 24 (2023-12-01), Heft 23, S. 16845-16857
Online
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Zugriff:
Most Prostate Specific Membrane Antigens (PSMAs) targeting small molecules accumulate in the salivary glands (SGs), raising concerns about SG toxicity, especially after repeated therapies or therapy with 225Ac-labeled ligands. SG toxicity is assessed clinically by the severity of patient-reported xerostomia, but this parameter can be challenging to objectively quantify. Therefore, we explored the feasibility of using SG volume as a biomarker for toxicity. In 21 patients with late-stage metastatic resistant prostate cancer (mCRPC), the PSMA volume and ligand uptake of SG were analyzed retrospectively before and after two cycles of 177Lu-PSMA (LuPSMA; cohort A) and before and after one cycle of 225Ac-PSMA-617 (AcPSMA, cohort B). Mean Volume-SG in cohort A was 59 ± 13 vs. 54 ± 16 mL (−10%, p = 0.4), and in cohort B, it was 50 ± 13 vs. 40 ± 11 mL (−20%, p = 0.007), respectively. A statistically significant decrease in the activity concentration in the SG was only observed in group B (SUVmean: 9.2 ± 2.8 vs. 5.3 ± 1.8, p < 0.0001; vs. A: SUVmean: 11.2 ± 3.3 vs. 11.1 ± 3.5, p = 0.8). SG volume and PSMA-ligand uptake are promising markers to monitor the SG toxicity after a PSMA RLT. [ABSTRACT FROM AUTHOR]
Titel: |
Comparative Analysis of Morphological and Functional Effects of 225 Ac- and 177 Lu-PSMA Radioligand Therapies (RLTs) on Salivary Glands.
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Autor/in / Beteiligte Person: | Feuerecker, Benedikt ; Gafita, Andrei ; Langbein, Thomas ; Tauber, Robert ; Seidl, Christof ; Bruchertseifer, Frank ; Gschwendt, Jürgen E. ; Weber, Wolfgang A. ; D'Alessandria, Calogero ; Morgenstern, Alfred ; Eiber, Matthias |
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Zeitschrift: | International Journal of Molecular Sciences, Jg. 24 (2023-12-01), Heft 23, S. 16845-16857 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1661-6596 (print) |
DOI: | 10.3390/ijms242316845 |
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