Resistant Hypertension and Related Outcomes in a Cohort of Patients with Cardiorenal Multimorbidity Hospitalized in an Internal Medicine Ward.
In: High Blood Pressure & Cardiovascular Prevention, Jg. 30 (2023-11-01), Heft 6, S. 585-590
Online
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Zugriff:
Introduction: Resistant hypertension (RH) is characterized by the failure to reach a goal blood pressure despite the administration of three medications at maximally tolerated doses, one of which being a diuretic. RH can be observed in a variety of clinical conditions, such as heart failure and reduced renal function and may confer high cardiovascular risk. Aim: To evaluate the prevalence of RH and its association with clinical outcomes; the primary outcome was in-hospital mortality and the composite outcome was all-cause of mortality and morbidity in a cohort of patients with cardiorenal multimorbidity hospitalized in an internal medicine ward. Methods: We conducted a retrospective analysis of consecutive hypertensive patients with cardiorenal multimorbidity. The composite outcome incorporated all-cause of in-hospital mortality and occurrence of sepsis, pulmonary embolism, acute coronary syndrome, stroke and renal replacement therapy. Results: We collected data in 141 inpatients with a mean age of 77 years ± 10 (males 65.9 %), estimated glomerular filtration rate of 34 ± 18.6 ml/min with length of stay of 17 ± 12 days. The prevalence of RH was 52.4%. In-hospital mortality was observed in 24 patients (17%) and the composite outcome occurred in 87 patients (61.7%) and among these 74 (85.1%) were patients with RH. Free survival for composite outcome was significantly higher in patients without RH than patients with RH (log rank 7.52, p = 0.006). Resistant hypertension was a risk factor for composite outcome [HR 1.857(C.I. 1.170–2.946, p = 0.009)]. Conclusion: In patients with cardiorenal multimorbidity there is a high proportion of RH that represents a risk factor for composite outcome but not for in-hospital mortality. [ABSTRACT FROM AUTHOR]
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Resistant Hypertension and Related Outcomes in a Cohort of Patients with Cardiorenal Multimorbidity Hospitalized in an Internal Medicine Ward.
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Autor/in / Beteiligte Person: | Gigante, Antonietta ; Cianci, Rosario ; Brigato, Claudia ; Melena, Michele ; Acquaviva, Erika ; Toccini, Ludovica ; Pellicano, Chiara ; Rosato, Edoardo ; Muscaritoli, Maurizio |
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Zeitschrift: | High Blood Pressure & Cardiovascular Prevention, Jg. 30 (2023-11-01), Heft 6, S. 585-590 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 1120-9879 (print) |
DOI: | 10.1007/s40292-023-00609-x |
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