Comparison of Serum Levels of Interleukin 17 and Interleukin 9 in Leprosy Patients with and without Lepra Reaction: A Cross-Sectional Analytical Study from Central India.
In: Indian Journal of Dermatology, Jg. 68 (2023-11-01), Heft 6, S. 661-665
Online
academicJournal
Zugriff:
New pathways of host defence have emerged in leprosy, such as T helper (Th)-17, Th-9, T regulatory cells, and other factors like transforming growth factor-beta, etc. Interleukin (IL) 17 produced by Th17 cells has been found to be elevated in lepra reaction, especially type 2 lepra reaction (T2R). Role of IL-9 has not been studied widely in leprosy reactions so far. The study aimed to compare serum levels of IL-17 and IL-9 in leprosy patients with and without lepra reaction. This was a cross-sectional analytical study including untreated adult leprosy patients with and without lepra reaction. A total of 65 patients were included in the study with 30 leprosy patients without reaction and 35 with lepra reaction. Serum levels of IL-17 and IL-9 were measured in these patients using direct enzyme-linked immunosorbent assay and were compared. Borderline tuberculoid (BT) leprosy with type 1 and Lepromatous (LL) leprosy with T2R patients showed significantly higher levels of IL-17 than BT and LL leprosy patients without lepra reaction, respectively. LL patients with T2R showed significantly lower levels of IL-9 than lepromatous cases without reaction. IL-9 levels were higher in BT patients with T1R as compared to BT patients without reaction but the difference was not significant. We found evidence in support of role of IL-17 in the pathogenesis of T2R, which might serve as useful serum markers for the same. IL-17 might have a role in BT leprosy with T1R. IL-9 seems to have a protective role in T2R as opposed to IL-17, working in synergism with Th1 cytokines. [ABSTRACT FROM AUTHOR]
Titel: |
Comparison of Serum Levels of Interleukin 17 and Interleukin 9 in Leprosy Patients with and without Lepra Reaction: A Cross-Sectional Analytical Study from Central India.
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Autor/in / Beteiligte Person: | Choudhary, Ritul ; Chhabra, Namrata ; Patel, Suprava |
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Zeitschrift: | Indian Journal of Dermatology, Jg. 68 (2023-11-01), Heft 6, S. 661-665 |
Veröffentlichung: | 2023 |
Medientyp: | academicJournal |
ISSN: | 0019-5154 (print) |
DOI: | 10.4103/ijd.ijd_357_23 |
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