Cisplatin Resistance May Be Caused by Domino Effect of Hyperactive Signals.
In: Pharmacy Times Oncology Edition, Jg. 5 (2023-10-01), Heft 7, S. 35-36
serialPeriodical
Zugriff:
A study conducted in the Republic of Korea and the United States has found that cisplatin resistance in tumor cells may be caused by hyperactive signaling of the EGFR/AKT pathway. The study suggests that inhibiting TRPV1, a nonselective cation channel mediated by NANOG, can overcome cisplatin resistance by blocking autophagy-mediated hyperactivation of the EGFR signaling pathway. The researchers also found that high expression of NANOG/TRPV1 decreased the overall survival rate of patients with cervical cancer. Targeted therapies that inhibit TRPV1 could potentially sensitize treatment-resistant cancer cells to chemotherapy and reduce chemotherapy-induced neuropathic pain. [Extracted from the article]
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Cisplatin Resistance May Be Caused by Domino Effect of Hyperactive Signals.
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Autor/in / Beteiligte Person: | HUNTER, ERIN |
Zeitschrift: | Pharmacy Times Oncology Edition, Jg. 5 (2023-10-01), Heft 7, S. 35-36 |
Veröffentlichung: | 2023 |
Medientyp: | serialPeriodical |
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