Association between serum CXC chemokine ligand 17 and type 2 diabetes mellitus with non-alcoholic fatty liver disease.
In: Chinese Journal of Diabetes Mellitus, Jg. 16 (2024-02-01), Heft 2, S. 214-219
academicJournal
Zugriff:
Objective To investigate the association between the serum CXC chemokine ligand 17 (CXCL17) and type 2 diabetes mellitus (T2DM) with non-alcoholic fatty liver disease (NAFLD). Methods This was a cross-sectional study. Newly diagnosed T2DM patients hospitalized at the Department of Endocrinology of the First Affiliated Hospital of Soochow University from April 2021 to December 2022 and the healthy volunteers in the physical examination center during the same period were selected as the control group. Height and weight of the participants were collected, body mass index (BMI) was calculated, CXCL17, low-density lipoprotein-cholesterol (LDL-C) and glutamic pyruvic transaminase (ALT) were detected, and hepatic fat fraction (HFF) was measured. According to HFF, patients with T2DM but without NAFLD were assigned to T2DM group (HFF≤5.5%), and patients with T2DM and NAFLD were assigned to T2DM+NAFLD group (HFF> 5.5%). One-way analysis of variance (ANOVA), Kruskal-Wallis H test and χ² test were used for comparisons between groups, Spearman correlation analysis was used to analyze the correlation between HFF and other variables, and binary logistic regression analysis was used to analyze the independent influencing factors of T2DM patients with NAFLD. Results Two hundred and seventy patients were enrolled. Of these, 88 were in T2DM group, 92 in T2DM+NAFLD group and 90 in control group. The level of serum CXCL17 in T2DM+NAFLD group [(95.62±6.83) ng/L] was higher than that in T2DM group [(56.49±9.45) ng/L] and control group [(21.59±5.12) ng/L] (P<0.05). Spearman correlation analysis showed that HFF was positively correlated with CXCL17 (r=0.672), BMI (r=0.481), ALT (r=0.447), LDL-C (r=0.253), respectively (all P<0.001). Binary logistic regression showed that CXCL17(OR=0.949,95%CI 0.926-0.973), BMI(OR=0.773,95%CI 0.678-0.882), ALT(OR= 0.943, 95%CI 0.918-0.968), LDL-C(OR=0.632, 95%CI 0.432-0.923) were independent influencing factors of NAFLD (P<0.05). Conclusion The increase of serum CXCL17 might be an independent risk factor of NAFLD. [ABSTRACT FROM AUTHOR]
Titel: |
Association between serum CXC chemokine ligand 17 and type 2 diabetes mellitus with non-alcoholic fatty liver disease.
|
---|---|
Autor/in / Beteiligte Person: | Yan, Zhu ; Jingcheng, Hu ; Mengjiao, Wu ; Xuan, Du ; Huijuan, Li ; Bimin, Shi |
Zeitschrift: | Chinese Journal of Diabetes Mellitus, Jg. 16 (2024-02-01), Heft 2, S. 214-219 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1674-5809 (print) |
DOI: | 10.3760/cma.j.cn115791-20231007-00219 |
Sonstiges: |
|