甲状腺与脂肪组织间相互作用研究进展.

Obesity is caused by excessive energy intake and reduced consumption，when the energy intake exceeds the containing capacity of adipose tissue（AT），AT undergoes functional disorders and triggers a series of metabolic related changes. Thyroid gland， being the key organ regulating the energy metabolism of the body，it exerts an profound influence on the adipose tissue，the main energy storage organ. It can regulate the glucose and lipid metabolism，mitochondrial function and phenotype change of adipose tissue through direct and indirect effects，and has an indispensable impact on the occurrence and development of obesity and metabolic syndrome. In the past，researches on thyroid and fat mostly focused on the unilateral effect of thyroid on adipose tissue，while it’s been recently pointed out that adipose tissue can also affect thyroid function through lipotoxicity，secretion of adipokine and proinflammatory factors， leading to thyroid diseases such as thyroid nodules，thyroid dysfunction. This article describes the interaction between thyroid and adipose tissue and its role in the occurrence and development of obesity related diseases and thyroid related diseases. [ABSTRACT FROM AUTHOR]

肥胖由能量摄入过多及消耗减少所致，当摄入的能量超过脂肪组织的承受极限时，脂肪组织出现功能失调并引发 一系列代谢相关改变。甲状腺是调控机体能量代谢的核心器官，对作为主要储能器官的脂肪组织具有重要的调节作用，可通 过直接与间接作用调节脂肪组织的糖脂代谢、线粒体功能及表型转化等，对肥胖及代谢综合征的发生发展有着不可或缺的影 响。过去，人们对甲状腺与脂肪的研究多停留在甲状腺对脂肪组织的单方面影响，新近研究发现脂肪组织亦可通过脂毒性、分 泌脂肪因子及促炎因子等途径，导致甲状腺结节、甲状腺功能异常等甲状腺疾病的发生。本文将综述甲状腺与脂肪组织的相 互作用及其在肥胖与甲状腺相关疾病发生发展中的作用。 [ABSTRACT FROM AUTHOR]