Non-Faradaic aptasensor based on NH<subscript>2</subscript>-GO/PPy for the detection of 17β-estradiol.
In: Journal of the Iranian Chemical Society, Jg. 21 (2024-05-01), Heft 5, S. 1213-1223
Online
academicJournal
Zugriff:
17ß-Estradiol (E2) is an endocrine-disrupting chemical that has become a matter of concern across the globe for more than a decade due to potential health risks. This study reports facile methods to fabricate label-free aptasensor based on the non-Faradaic impedance mode using amine-functionalized graphene oxide polypyrrole (NH2-GO/PPy)-modified gold interdigitated electrode for direct capacitive detection of 17β-estradiol. The as-prepared NH2-GO/PPy nanocomposites have been successfully characterized by field-emission scanning electron microscopy (FESEM), atomic force microscopy, Fourier transform infrared spectroscopy, and electrochemical impedance spectroscopy. The results show that NH2-GO/PPy/IDE was able to detect E2 binding through aptamer conformational change by simply observing the capacitance change before and after immobilization. In addition, the biosensor showed a dynamic range of detection from 100 nM to 1 pM with a low detection limit of about 0.13 pM. The recoveries result also presented in this paper was validated using HPLC exhibited high sensitivity for bisphenol-A (BPA) detection and was successfully applied to detect E2 in real water samples with good recoveries. [ABSTRACT FROM AUTHOR]
Titel: |
Non-Faradaic aptasensor based on NH<subscript>2</subscript>-GO/PPy for the detection of 17β-estradiol.
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Autor/in / Beteiligte Person: | Waheed, Anjam ; Mat Zaid, Mohd H. ; Ismail, Suhainie ; Hussain, Afifuddin H. ; Mohd Razip Wee, M. F. |
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Zeitschrift: | Journal of the Iranian Chemical Society, Jg. 21 (2024-05-01), Heft 5, S. 1213-1223 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 1735-207X (print) |
DOI: | 10.1007/s13738-024-02987-y |
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