Simultaneous Screening of 172 Veterinary Drugs by Modified QuEChERS-LC–MS/MS in TCM Galli Gigerii Endothelium Corneum.
In: Journal of Chromatographic Science, Jg. 62 (2024-05-01), Heft 5, S. 439-443
academicJournal
Zugriff:
An analytical method was developed for the screening of 172 veterinary drugs in traditional Chinese medicine Galli Gigerii Endothelium Corneum by high-performance liquid chromatography tandem mass spectrometry. The samples were pretreated by a modified QuEChERS method. A Zorbax Eclipse plus C18 column (1.8 μm, 3.0 × 150 mm2, Agilent) was used for the separation of analytes by gradient elution. All analytes were detected by electrospray ionization mass spectrometry with multiple reaction monitoring mode. Good linearity with R ≥ 0.99 was exhibited for all analytes within the respective range. The recoveries of all monitored analytes ranged from 55.4 to 127.6% at three spiked levels (limit of quantitation—LOQ, 2-fold LOQ, 10-fold LOQ), with relative standard deviations <17.8%. The estimated LOQ levels were 0.2–20 μg/kg. The application of this method provides a reference for the safety control of traditional Chinese medicines. [ABSTRACT FROM AUTHOR]
Titel: |
Simultaneous Screening of 172 Veterinary Drugs by Modified QuEChERS-LC–MS/MS in TCM Galli Gigerii Endothelium Corneum.
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Autor/in / Beteiligte Person: | Hu, Qing ; Sun, Jian ; Yu, Hong ; Feng, Rui ; Zhang, Jingxian ; Zhou, Heng ; Ji, Shen |
Zeitschrift: | Journal of Chromatographic Science, Jg. 62 (2024-05-01), Heft 5, S. 439-443 |
Veröffentlichung: | 2024 |
Medientyp: | academicJournal |
ISSN: | 0021-9665 (print) |
DOI: | 10.1093/chromsci/bmae014 |
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