我国中老年群体社会参与和认知功能 与衰弱发生关系的研究.

Objective To investigate whether there is a mediating effect of cognitive function between social participation and frailty. Methods Using the China Health and Retirement Longitudinal Survey (CHARLS) database, three rounds of survey data in 2011, 2013, and 2015 were selected for the study. The data in 2011 were the baseline data, and the ID number was used to match the participants in the follow-up in 2013 and 2015. A total of 3 139 people were enrolled in this cohort study. Cox regression model and simple mediating effect model were used to analyze the relationship among social participation, cognitive function, and frailty. Results A total of 259 patients had frailty during the follow -up period. The results of multivariate Cox regression model adjusting social demography and lifestyle showed that social participation (ffl =0.641, 95% CI: 0.496-0.829) and cognitive function (HR=0.952, 95%CI: 0.928-0.977) were associated with frailty. The results of the intermediary model with relevant covariates showed that cognitive function has a significant mediating effect between social participation and frailty. Conclusion Social participation and cognitive function are associated with frailty, and cognitive function has some mediating effect between social participation and frailty. [ABSTRACT FROM AUTHOR]

目的了解认知功能在社会参与和衰弱之间是否存在中介效应。方法利用"中国健康与养老追踪调查" (China Health and Retirement Longitudinal Survey, CHARLS)数据库, 选择 2011,2013 和 2015 年三轮调查数据进行研究,2011 年 的数据为人组基线数据, 并以ID号匹配2013和2015年参与随访的研究对象,筛选过后共有3 139人纳人本次队列研 究。采用Cox回归模型和简单中介效应模型来分析社会参与、认知功能和衰弱发生之间的关系。结果 在随访期间共有 259人岀现了新发衰弱,调整了社会人口学和生活方式的多因素Cox回归模型结果显示, 社会参与(血=0.641,95%CI： 0.496 ~ 0.829)和认知功能(M=0.952,95%C：0.928 ~ 0.977)与衰弱发生相关。纳人相关协变量的中介模型结果显示, 认 知功能在社会参与和衰弱之间的中介效应显著。结论社会参与和认知功能与衰弱发生相关, 认知功能在社会参与和 衰弱之间存在部分中介效应。 [ABSTRACT FROM AUTHOR]