Correlation of inhibitor of differentiation 1 expression to tumor progression, poor differentiation and aggressive behaviors in cervical carcinoma
In: Gynecologic Oncology, Jg. 114 (2009-07-01), Heft 1, S. 89-93
academicJournal
Zugriff:
Abstract: Objective: To study the correlation of inhibitor of differentiation 1 (Id-1) to tumor invasion and metastasis by examining Id-1 expression levels in different stages of cervical carcinogenesis. Methods: Id-1 mRNA and protein expression was detected in total of 171 cervical samples including precancerous and cancerous tissues by quantitative RT-PCR (qRT-PCR) and immunohistochemistry (IHC), respectively. Twenty-five normal cervical tissues were used as a normal control. Correlation between Id-1 positive rates and expression levels to cancer progression and clinicopathologic features was statistically analyzed. Results: A gradual increase of Id-1 protein expression associated with cervical cancer progression was detected (4%, 16%, 50% and 75.9% in normal, low squamous intraepithelial lesion (LSIL), high squamous intraepithelial lesion (HSIL) and cancer tissue, respectively, p <0.001). A similar trend of Id-1 mRNA expression was also observed (1.3, 3.4 and 10.4 fold higher than normal tissues in LSIL, HSIL and cancer tissue, respectively, p <0.001). Furthermore, the Id-1 expression level was correlated to tumor grade (p =0.005), lymph node metastasis (p =0.001), interstitial invasive (p <0.001) and tumor size (p <0.001). These results suggest that high Id-1 expression is associated with tumor growth, invasion and metastasis. Conclusion: Id-1 expression is correlated to progression and aggressive behaviors in cervical cancer, suggesting a tumor-promoting role for Id-1 in progression of this malignancy. [Copyright &y& Elsevier]
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Correlation of inhibitor of differentiation 1 expression to tumor progression, poor differentiation and aggressive behaviors in cervical carcinoma
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Autor/in / Beteiligte Person: | Li, Jinke ; Jia, Haijun ; Xie, Lingxia ; Wang, Xia ; He, Haining ; Lin, Yong ; Hu, Lina |
Zeitschrift: | Gynecologic Oncology, Jg. 114 (2009-07-01), Heft 1, S. 89-93 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 0090-8258 (print) |
DOI: | 10.1016/j.ygyno.2009.03.016 |
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