Up-regulation and clinical relevance of novel helicase homologue DHX32 in colorectal cancer.
In: Journal of Experimental & Clinical Cancer Research (17569966), Jg. 28 (2009), S. 1-7
Online
academicJournal
Zugriff:
Background: This study aimed to find novel biomarkers for colorectal cancer. Methods: Fluorescent mRNA differential display PCR (DD-PCR) was used to screen the genes differentially expressed in colorectal cancer tissues and their adjacent tissues. The differentially expressed genes were confirmed by real-time PCR and then their clinical relevance (such as association with tumor location and lymph gland metastasis) was further investigated. Results: We identified by DD-PCR a novel RNA helicase, DHX32, which showed higher expression in colorectal cancer tissues than their adjacent tissues, and this result was confirmed by real time RT-PCR. In addition, we found that the level of DHX32 gene expression in colorectal cancer was significantly associated with cancer location, lymph gland metastasis, cancer nodal status, differentiation grade, and Dukes, stage. Conclusion: DHX32 may play an important role in the development of colorectal cancer and could serve as a novel biomarker for colorectal cancer after additional investigation. [ABSTRACT FROM AUTHOR]
Titel: |
Up-regulation and clinical relevance of novel helicase homologue DHX32 in colorectal cancer.
|
---|---|
Autor/in / Beteiligte Person: | Huang, Chunling ; Liang, Xianming ; Huang, Ruxin ; Zhang, Zhongying |
Link: | |
Zeitschrift: | Journal of Experimental & Clinical Cancer Research (17569966), Jg. 28 (2009), S. 1-7 |
Veröffentlichung: | 2009 |
Medientyp: | academicJournal |
ISSN: | 1756-9966 (print) |
DOI: | :10.1186/1756-9966-28-11 |
Schlagwort: |
|
Sonstiges: |
|