Loss of balance between T helper type 17 and regulatory T cells in chronic human immunodeficiency virus infection.
In: Clinical & Experimental Immunology, Jg. 165 (2011-09-01), Heft 3, S. 363-371
Online
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Zugriff:
Summary The aim of this study is to characterize the changes of CD4+CD25highforkhead box P3 (FoxP3+) regulatory T cells (Treg), interleukin (IL)-17 secreting T helper type 17 (Th17) cell frequencies and the balance of these two subsets in a cohort of chronic human immunodeficiency virus type 1 (HIV-1)-infected patients in China. A total of 115 untreated chronic HIV-infected individuals and 32 healthy donors were recruited in this study. Peripheral blood mononuclear cells were isolated from ethylenediamine tetracetic acid (EDTA) anti-coagulated fresh whole blood and stained to characterize the frequencies of Treg and Th17. Of a total 115 patients, 42 individuals including 10 elite controllers were followed-up for more than 1 year, and changes of Treg and Th17 frequencies were analysed over time. The continuous loss of Th17 cells was accompanied by a concomitant rise in the frequency of Treg cells, resulting in a loss of Th17/Treg balance during the progressive HIV infection. Meanwhile, the Treg levels, Th17 levels and Th17/Treg ratios of the elite controller group were comparable to those of the HIV-1 negative controls in the follow-up study. Additionally, we demonstrated that loss of balance between Th17 and Treg is associated with an earlier CD4 T cell decline during the course of HIV infection. Our results indicate that a loss of immune-balance of Th17 to Treg during HIV-1 disease progression and the persistence of such an immune-balance in the elite controllers may have a critical role in HIV-1 infection and further shed new light into understanding the pathogenesis of HIV-1. [ABSTRACT FROM AUTHOR]
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Loss of balance between T helper type 17 and regulatory T cells in chronic human immunodeficiency virus infection.
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Autor/in / Beteiligte Person: | Li, D. ; Chen, J. ; Jia, M. ; Hong, K. ; Ruan, Y. ; Liang, H. ; Liu, S. ; Zhang, X. ; Zhao, H. ; Peng, H. ; Ma, P. ; Shao, Y. |
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Zeitschrift: | Clinical & Experimental Immunology, Jg. 165 (2011-09-01), Heft 3, S. 363-371 |
Veröffentlichung: | 2011 |
Medientyp: | academicJournal |
ISSN: | 0009-9104 (print) |
DOI: | 10.1111/j.1365-2249.2011.04435.x |
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