17β-Estradiol enhances response of mice spleen B cells elicited by TLR9 agonist
In: Cellular Immunology, Jg. 278 (2012-07-15), Heft 1/2, S. 125-135
academicJournal
Zugriff:
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies against nucleic acid-associated antigens. B cells play cardinal roles in SLE. Many evidences have proved estrogen contribute to the gender bias in SLE and 17β-estradiol (E2) could accelerate the disease by regulating B cells. On the other hand, B cells express TLR9 which recognized dsDNA and played a critical role in SLE. However, the crosstalk between estrogen and TLR9 in B cells remains unknown. So we investigated the E2 effect in the presence of the TLR9 ligand CpG on mice spleen B cells. We found that the up-regulation of cell viability, life-span, co-stimulation molecules (CD40, CD86) expression, IgM secretion, TLR9 and MCM6 expression were more significant than CpG ODN or E2 stimulated alone. It may provide a new way to investigate the mechanism of how E2 modulate the B cells function in lupus. [Copyright &y& Elsevier]
Titel: |
17β-Estradiol enhances response of mice spleen B cells elicited by TLR9 agonist
|
---|---|
Autor/in / Beteiligte Person: | Xu, Yixin ; Fan, Hongye ; Li, Xiaoxi ; Sun, Lingyun ; Hou, Yayi |
Zeitschrift: | Cellular Immunology, Jg. 278 (2012-07-15), Heft 1/2, S. 125-135 |
Veröffentlichung: | 2012 |
Medientyp: | academicJournal |
ISSN: | 0008-8749 (print) |
DOI: | 10.1016/j.cellimm.2012.07.007 |
Schlagwort: |
|
Sonstiges: |
|