Patient-Reported Discontinuation of Endocrine Therapy and Related Adverse Effects Among Women With Early-Stage Breast Cancer.
In: Journal of Oncology Practice, Jg. 8 (2012-11-01), Heft 6, S. e149- (9S.)
Online
academicJournal
Zugriff:
Background: Approximately 20% to 50% of women diagnosed with hormone receptor-positive breast cancer discontinue endocrine therapy early; most reports come from automated pharmacy data or small self-report evaluations .We conducted a larger self-report evaluation of endocrine therapy discontinuation associated with patient characteristics and therapy-related adverse effects. Methods: We surveyed 538 women from a single health plan who were diagnosed with early-stage breast cancer from 2002 to 2008 and received endocrine therapy. Women reported adverse effects and reasons for discontinuation via mailed survey; tumor characteristics were obtained via registry linkage.We classified women as discontinuers if they self-reported stopping therapy and their self-reported duration oft amoxifen plus aromatase inhibitor (AI) use was < 5 years, and nondiscontinuers if they self-reported ≥ 5 years use or currentuse. We estimated odds ratios (ORs) with 95% CIs for discontinuation versus continuation by using logistic regression adjusted for age and year of diagnosis. Results: Among 538 women, 98 (18.2%) discontinued endocrinetherapy early. Women with positive lymph nodes (v negative) were significantly less likely to discontinue therapy (odds ratio [OR] = 0.54; 95% CI, 0.31 to 0.93). Almost all women (94%)experienced adverse effects. Experiencing headaches was associated with discontinuation of AIs (OR = 4.16; 95% CI, 2.16 to 8.01) and tamoxifen (OR=2.34; 95% CI, 1.24 to 4.41); few other individual adverse effects were related to discontinuation despite most discontinuers reporting they "did not like adverse effects" (AIs: 66.7%, tamoxifen: 59.1%). Conclusion: Few individual adverse effects or patient characteristics were significantly associated with endocrine therapy discontinuation, yet adverse effects were prevalent and were the most common reason women reported for discontinuing therapy. [ABSTRACT FROM AUTHOR]
Titel: |
Patient-Reported Discontinuation of Endocrine Therapy and Related Adverse Effects Among Women With Early-Stage Breast Cancer.
|
---|---|
Autor/in / Beteiligte Person: | Bowles, Erin J. Aiello ; Boudreau, Denise M. ; Chubak, Jessica ; Yu, Onchee ; Fujii, Monica ; Chestnut, Janet ; M. Buist, Diana S. |
Link: | |
Zeitschrift: | Journal of Oncology Practice, Jg. 8 (2012-11-01), Heft 6, S. e149- (9S.) |
Veröffentlichung: | 2012 |
Medientyp: | academicJournal |
ISSN: | 1554-7477 (print) |
DOI: | 10.1200/JOP.2012.000543 |
Schlagwort: |
|
Sonstiges: |
|