MRI assessment of experimental gliomas using 17.6 T.
In: Neuroradiology, Jg. 55 (2013-06-01), Heft 6, S. 709-718
Online
academicJournal
Zugriff:
Introduction: Using ultra-high-field contrast-enhanced magnetic resonance imaging (MRI), an increase of field strength is associated with a decrease of T relaxivity. Yet, the impact of this effect on signal characteristics and contrast-enhanced pathology remains unclear. Hence, we evaluated the potential of a 17.6-T MRI to assess contrast-enhancing parts of experimentally induced rat gliomas compared to 3 T. Methods: A total of eight tumor-bearing rats were used for MRI assessments either at 17.6 T (four rats) or at 3 T (four rats) at 11 days after stereotactic implantation of F98 glioma cells into the right frontal lobe. T-weighted sequences were used to investigate signal-to-noise-ratios, contrast-to-noise-ratios, and relative contrast enhancement up to 16 min after double-dose contrast application. In addition, tumor volumes were calculated and compared to histology. Results: The 17.6-T-derived contrast-enhancing volumes were 31.5 ± 15.4 mm at 4 min, 38.8 ± 12.7 mm at 8 min, 51.1 ± 12.6 mm at 12 min, and 61.5 ± 10.8 mm at 16 min after gadobutrol injection. Corresponding histology-derived volumes were clearly higher (138.8 ± 8.4 mm; P < 0.01). At 3 T, contrast-enhancing volumes were 85.2 ± 11.7 mm at 4 min, 107.3 ± 11.0 mm at 8 min, 117.0 ± 10.5 mm at 12 min, and 129.1 ± 10.0 mm at 16 min after contrast agent application. Averaged histology-derived volumes (139.1 ± 13.4 mm) in this group were comparable to the 16-min volume ( P = 0.38). Compared to ultra-high-field MRI, all 3-T-derived volumes were significantly higher ( P < 0.02). Conclusion: Compared to 3-T-derived images and histology, tumor volumes were underestimated by approximately 50 % at 17.6 T. Hence, contrast-enhanced 17.6-T MRI provided no further benefits in tumor measurement compared to 3 T. [ABSTRACT FROM AUTHOR]
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MRI assessment of experimental gliomas using 17.6 T.
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Autor/in / Beteiligte Person: | Schwarz, Marc ; Pham, Mirko ; Helluy, Xavier ; Doerfler, Arnd ; Engelhorn, Tobias |
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Zeitschrift: | Neuroradiology, Jg. 55 (2013-06-01), Heft 6, S. 709-718 |
Veröffentlichung: | 2013 |
Medientyp: | academicJournal |
ISSN: | 0028-3940 (print) |
DOI: | 10.1007/s00234-013-1149-6 |
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