Genetically predicted 17β-estradiol and systemic inflammation in women: a separate-sample Mendelian randomisation analysis in the Guangzhou Biobank Cohort Study.
In: Journal of Epidemiology & Community Health, Jg. 68 (2014-08-01), Heft 8, S. 780-785
Online
academicJournal
Zugriff:
Background Many chronic diseases are characterised by low-grade systemic inflammation. Oestrogens may promote immune response consistent with sex-specific patterns of diseases. In vitro culture and animal experiments suggest oestrogens are anti-inflammatory and might thereby protect against low-grade systemic inflammation. Evidence from epidemiological studies is limited. Using a Mendelian randomisation analysis with a separate-sample instrumental variable (SSIV) estimator, we examined the association of genetically predicted 17β-estradiol with well-established systemic inflammatory markers (total white cell count, granulocyte and lymphocyte count). Methods A genetic score predicting 17β-estradiol was developed in 237 young Chinese women (university students) from Hong Kong based on a parsimonious set of genetic polymorphisms (ESR1 (rs2175898) and CYP19A1 (rs1008805)). Multivariable linear regression was used to examine the association of genetically predicted 17β-estradiol with systemic inflammatory markers among 3096 older (50+ years) Chinese women from the Guangzhou Biobank Cohort Study. Results Predicted 17β-estradiol was negatively associated with white blood cell count (−6.3 103/mL, 95% CI −11.4 to −1.3) and granulocyte count (−4.5 103/mL, 95% CI −8.5 to −0.4) but not lymphocyte count (−1.5 103/mL, 95% CI −3.4 to 0.4) adjusted for age only. Results were similar further adjusted for education, smoking, use of alcohol, physical activity, Body Mass Index, waist-hip ratio, age of menarche, age at menopause, use of hormonal contraceptives and hormone replacement therapy. Conclusions Endogenous genetically predicted 17β-estradiol reduced low-grade systemic inflammatory markers (white blood cell count and granulocyte count), consistent with experimental and ecological evidence of 17β-estradiol promoting immune response. Replication in a larger sample is required. [ABSTRACT FROM AUTHOR]
Titel: |
Genetically predicted 17β-estradiol and systemic inflammation in women: a separate-sample Mendelian randomisation analysis in the Guangzhou Biobank Cohort Study.
|
---|---|
Autor/in / Beteiligte Person: | Zhao, J. ; Jiang, C. Q. ; Lam, T. H. ; Liu, B. ; Cheng, K. K. ; Kavikondala, S. ; Zhang, W. S. ; Leung, G. M. ; Schooling, C. M. |
Link: | |
Zeitschrift: | Journal of Epidemiology & Community Health, Jg. 68 (2014-08-01), Heft 8, S. 780-785 |
Veröffentlichung: | 2014 |
Medientyp: | academicJournal |
ISSN: | 0143-005X (print) |
DOI: | 10.1136/jech-2013-203451 |
Schlagwort: |
|
Sonstiges: |
|