Orphan receptors COUP-TF and DAX-1 as targets in disordered CYP17 expression in adrenocortical tumors.
In: Endocrine research, Jg. 26 (2000-11-01), Heft 4, S. 1039-44
Online
academicJournal
Zugriff:
CYP17 gene transcription is activated by SF-1 binding to a cyclic AMP-responsive sequence within the promoter region of the gene, and its transcription is inhibited by COUP-TF binding to the sequence. Another orphan receptor, DAX-1, is shown to act as a suppressor of SF-1-mediated transcription. We examined the expression level of these orphan receptors in adrenocortical tumors and compared the results with CYP17 expression. CYP17 was highly expressed in cortisol-producing adenomas, whereas COUP-TF and DAX-1 expression levels were very low. In deoxycorticosterone-producing adenomas, on the other hand, CYP17 expression was extremely low, whereas DAX-1 was highly expressed and SF-1 expression was slightly decreased. In conclusion, the reciprocal expression of CYP17 and the transcriptional repressors COUP-TF and DAX-1 indicates that these orphan receptors have a pathophysiologic role in the excessive hormone production in cortisol- and deoxycorticosterone-producing adrenocortical tumors.
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Orphan receptors COUP-TF and DAX-1 as targets in disordered CYP17 expression in adrenocortical tumors.
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Autor/in / Beteiligte Person: | Shibata, H ; Ikeda, Y ; Morohashi, K ; Mukai, T ; Kurihara, I ; Ando, T ; Suzuki, T ; Kobayashi, S ; Hayashi, K ; Hayashi, M ; Saito, I ; Saruta, T |
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Zeitschrift: | Endocrine research, Jg. 26 (2000-11-01), Heft 4, S. 1039-44 |
Veröffentlichung: | London : Informa Healthcare ; <i>Original Publication</i>: New York, N.Y. : Dekker, c1984-, 2000 |
Medientyp: | academicJournal |
ISSN: | 0743-5800 (print) |
DOI: | 10.3109/07435800009048636 |
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