Einzeltreffer — DigiBib

We have cloned a fusion partner of the MLL gene at 11q23 and identified it as the gene encoding the human formin-binding protein 17, FBP17. It maps to chromosome 9q34 centromeric to ABL. The gene fusion results from a complex chromosome rearrangement that was resolved by fluorescence in situ hybridization with various probes on chromosomes 9 and 11 as an ins(11;9)(q23;q34)inv(11)(q13q23). The rearrangement resulted in a 5'-MLL/FBP17-3' fusion mRNA. We retrovirally transduced murine-myeloid progenitor cells with MLL/FBP17 to test its transforming ability. In contrast to MLL/ENL, MLL/ELL and other MLL-fusion genes, MLL/FBP17 did not give a positive readout in a serial replating assay. Therefore, we assume that additional cooperating genetic abnormalities might be needed to establish a full malignant phenotype. FBP17 consists of a C-terminal Src homology 3 domain and an N-terminal region that is homologous to the cell division cycle protein, cdc15, a regulator of the actin cytoskeleton in Schizosaccharomyces pombe. Both domains are separated by a consensus Rho-binding motif that has been identified in different Rho-interaction partners such as Rhotekin and Rhophilin. We evaluated whether FBP17 and members of the Rho family interact in vivo with a yeast two-hybrid assay. None of the various Rho proteins tested, however, interacted with FBP17. We screened a human kidney library and identified a sorting nexin, SNX2, as a protein interaction partner of FBP17. These data provide a link between the epidermal growth factor receptor pathway and an MLL fusion protein.

Titel:	The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.
Autor/in / Beteiligte Person:	Fuchs, U ; Rehkamp, G ; Haas, OA ; Slany, R ; Kōnig, M ; Bojesen, S ; Bohle, RM ; Damm-Welk, C ; Ludwig, WD ; Harbott, J ; Borkhardt, A
Link:	Full Text Finder (Volltext)
Zeitschrift:	Proceedings of the National Academy of Sciences of the United States of America, Jg. 98 (2001-07-17), Heft 15, S. 8756-61
Veröffentlichung:	Washington, DC : National Academy of Sciences, 2001
Medientyp:	academicJournal
ISSN:	0027-8424 (print)
DOI:	10.1073/pnas.121433898
Schlagwort:	Artificial Gene Fusion Base Sequence Carrier Proteins genetics Cell Nucleus metabolism Cell Transformation, Neoplastic Chromosome Mapping DNA, Complementary DNA-Binding Proteins genetics Fatty Acid-Binding Proteins Histone-Lysine N-Methyltransferase Humans In Situ Hybridization, Fluorescence methods Infant Leukemia, Myelomonocytic, Acute genetics Leukemia, Myelomonocytic, Acute pathology Male Molecular Sequence Data Myeloid-Lymphoid Leukemia Protein Tissue Distribution Carrier Proteins metabolism Chromosomes, Human, Pair 9 DNA-Binding Proteins metabolism Leukemia, Myelomonocytic, Acute metabolism Proto-Oncogenes Transcription Factors Vesicular Transport Proteins
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Language: English [Proc Natl Acad Sci U S A] 2001 Jul 17; Vol. 98 (15), pp. 8756-61. <i>Date of Electronic Publication: </i>2001 Jul 03. MeSH Terms: Chromosomes, Human, Pair 9* ; Proto-Oncogenes* ; Transcription Factors* ; Vesicular Transport Proteins* ; Carrier Proteins / metabolism ; DNA-Binding Proteins / metabolism ; Leukemia, Myelomonocytic, Acute / *metabolism ; Artificial Gene Fusion ; Base Sequence ; Carrier Proteins / genetics ; Cell Nucleus / metabolism ; Cell Transformation, Neoplastic ; Chromosome Mapping ; DNA, Complementary ; DNA-Binding Proteins / genetics ; Fatty Acid-Binding Proteins ; Histone-Lysine N-Methyltransferase ; Humans ; In Situ Hybridization, Fluorescence / methods ; Infant ; Leukemia, Myelomonocytic, Acute / genetics ; Leukemia, Myelomonocytic, Acute / pathology ; Male ; Molecular Sequence Data ; Myeloid-Lymphoid Leukemia Protein ; Tissue Distribution References: Gene Ther. 1994 Mar;1(2):136-8. (PMID: 7584069) ; Oncogene. 1997 Oct 2;15(14):1681-7. (PMID: 9349501) ; Science. 1996 May 17;272(5264):1008-10. (PMID: 8638121) ; Semin Hematol. 1999 Oct;36(4 Suppl 7):59-72. (PMID: 10595755) ; Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9168-73. (PMID: 10908648) ; EMBO J. 2000 Sep 1;19(17):4655-64. (PMID: 10970858) ; Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10984-9. (PMID: 10995463) ; Blood. 2000 Dec 1;96(12):3887-93. (PMID: 11090074) ; Mol Biol Cell. 2000 Dec;11(12):4105-16. (PMID: 11102511) ; Nature. 1982 Dec 23;300(5894):765-7. (PMID: 6960256) ; Nature. 1990 Aug 30;346(6287):850-3. (PMID: 2392150) ; Nature. 1990 Aug 30;346(6287):853-5. (PMID: 2392151) ; Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10735-9. (PMID: 1720549) ; Mol Cell Biol. 1992 Apr;12(4):1687-97. (PMID: 1549122) ; Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5554-8. (PMID: 8516300) ; Mol Cell Biol. 1993 Sep;13(9):5814-28. (PMID: 7689153) ; Blood. 1993 Oct 1;82(7):2260-1. (PMID: 8400276) ; Oncogene. 1994 Apr;9(4):1039-45. (PMID: 8134107) ; Cancer Res. 1994 May 1;54(9):2327-30. (PMID: 8162575) ; Nature. 1994 Nov 10;372(6502):143-9. (PMID: 7969446) ; Mol Cell Biol. 1998 Jan;18(1):122-9. (PMID: 9418860) ; Genes Chromosomes Cancer. 1998 Mar;21(3):270-5. (PMID: 9523205) ; Leukemia. 1998 May;12(5):811-22. (PMID: 9593286) ; Proc Natl Acad Sci U S A. 1998 May 26;95(11):6413-8. (PMID: 9600980) ; Mol Cell Biol. 1998 Dec;18(12):7278-87. (PMID: 9819414) ; Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):680-5. (PMID: 9892693) ; Proc Natl Acad Sci U S A. 1999 May 25;96(11):6428-33. (PMID: 10339604) ; Br J Haematol. 1999 Sep;106(3):614-26. (PMID: 10468849) ; Mol Cell Biol. 1995 Oct;15(10):5820-9. (PMID: 7565735) ; J Biol Chem. 1996 Jun 7;271(23):13556-60. (PMID: 8662891) ; Genes Chromosomes Cancer. 1996 Jan;15(1):48-53. (PMID: 8824725) ; Lancet. 1997 Feb 1;349(9048):344-9. (PMID: 9024390) ; EMBO J. 1997 May 1;16(9):2376-83. (PMID: 9171351) ; Curr Biol. 1997 Jul 1;7(7):479-87. (PMID: 9210375) ; EMBO J. 1997 Jul 16;16(14):4226-37. (PMID: 9250666) ; EMBO J. 1996 Mar 1;15(5):1045-54. (PMID: 8605874) Molecular Sequence: GENBANK AF265550 Substance Nomenclature: 0 (Carrier Proteins) ; 0 (DNA, Complementary) ; 0 (DNA-Binding Proteins) ; 0 (FNBP1 protein, human) ; 0 (Fatty Acid-Binding Proteins) ; 0 (KMT2A protein, human) ; 0 (Transcription Factors) ; 0 (Vesicular Transport Proteins) ; 149025-06-9 (Myeloid-Lymphoid Leukemia Protein) ; EC 2.1.1.43 (Histone-Lysine N-Methyltransferase) Entry Date(s): Date Created: 20010705 Date Completed: 20010830 Latest Revision: 20201208 Update Code: 20240513 PubMed Central ID: PMC37508

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The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia.