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Ambient particulate air pollution assessed as outdoor concentrations of particulate matter less than or equal to 2.5 micro m in diameter (PM(2.5)) in urban background has been associated with cardiovascular diseases at the population level. However, the significance of individual exposure and the involved mechanisms remain uncertain. We measured personal PM(2.5) and carbon black exposure in 50 students four times in 1 year and analyzed blood samples for markers of protein and lipid oxidation, for red blood cell (RBC) and platelet counts, and for concentrations of hemoglobin and fibrinogen. We analyzed protein oxidation in terms of gamma-glutamyl semialdehyde in hemoglobin (HBGGS) and 2-aminoadipic semialdehyde in hemoglobin (HBAAS) and plasma proteins (PLAAS), and lipid peroxidation was measured as malondialdehyde (MDA) in plasma. Median exposures were 16.1 micro g/m(3) for personal PM(2.5) exposure, 9.2 micro g/m(3) for background PM(2.5) concentration, and 8.1 X 10(-6)/m for personal carbon black exposure. Personal carbon black exposure and PLAAS concentration were positively associated (p < 0.01), whereas an association between personal PM(2.5) exposure and PLAAS was only of borderline significance (p = 0.061). A 3.7% increase in MDA concentrations per 10 micro g/m(3) increase in personal PM(2.5) exposure was found for women (p < 0.05), whereas there was no significant relationship for the men. Similarly, positive associations between personal PM(2.5)exposure and both RBC and hemoglobin concentrations were found only in women (p < 0.01). There were no significant relationships between background PM(2.5) concentration and any of the biomarkers. This suggests that exposure to particles in moderate concentrations can induce oxidative stress and increase RBCs in peripheral blood. Personal exposure appears more closely related to these biomarkers potentially related to cardiovascular disease than is ambient PM(2.5) background concentrations.

Titel:	Personal PM2.5 exposure and markers of oxidative stress in blood.
Autor/in / Beteiligte Person:	Sørensen, M ; Daneshvar, B ; Hansen, M ; Dragsted, LO ; Hertel, O ; Knudsen, L ; Loft, S
Zeitschrift:	Environmental health perspectives, Jg. 111 (2003-02-01), Heft 2, S. 161
Veröffentlichung:	Research Triangle Park, N. C. National Institute of Environmental Health Sciences., 2003
Medientyp:	academicJournal
ISSN:	0091-6765 (print)
DOI:	10.1289/ehp.111-1241344
Schlagwort:	Adult Blood Proteins analysis Carbon adverse effects Erythrocyte Count Female Fibrinogen analysis Hemoglobins analysis Humans Lipid Peroxidation Male Particle Size Platelet Count Air Pollutants analysis Biomarkers analysis Environmental Exposure Oxidative Stress
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Environ Health Perspect] 2003 Feb; Vol. 111 (2), pp. 161-6. MeSH Terms: Environmental Exposure* ; Oxidative Stress* ; Air Pollutants / analysis ; Biomarkers / analysis ; Adult ; Blood Proteins / analysis ; Carbon / adverse effects ; Erythrocyte Count ; Female ; Fibrinogen / analysis ; Hemoglobins / analysis ; Humans ; Lipid Peroxidation ; Male ; Particle Size ; Platelet Count References: J Biol Chem. 2000 Aug 18;275(33):25130-8. (PMID: 10833514) ; Thorax. 1999 Nov;54(11):1027-32. (PMID: 10525563) ; Occup Environ Med. 2000 Dec;57(12):818-22. (PMID: 11077010) ; J Intern Med. 2000 Nov;248(5):377-86. (PMID: 11123502) ; Free Radic Biol Med. 2001 Mar 1;30(5):516-25. (PMID: 11182522) ; Circulation. 2001 Jun 12;103(23):2810-5. (PMID: 11401937) ; Chem Res Toxicol. 2001 Jul;14(7):879-87. (PMID: 11453735) ; Environ Health Perspect. 2001 Aug;109 Suppl 4:523-7. (PMID: 11544157) ; JAMA. 2002 Mar 6;287(9):1132-41. (PMID: 11879110) ; Br J Nutr. 2002 Apr;87(4):343-55. (PMID: 12064344) ; Proc Soc Exp Biol Med. 1975 Mar;148(3):774-6. (PMID: 1129298) ; Science. 1988 Dec 9;242(4884):1412-5. (PMID: 2849206) ; Atherosclerosis. 1992 Jun;94(2-3):93-107. (PMID: 1632876) ; N Engl J Med. 1993 Dec 9;329(24):1753-9. (PMID: 8179653) ; J Expo Anal Environ Epidemiol. 1996 Jan-Mar;6(1):57-78. (PMID: 8777374) ; Br J Haematol. 1997 Jan;96(1):168-73. (PMID: 9012704) ; Lancet. 1997 May 31;349(9065):1582-7. (PMID: 9174559) ; Environ Health Perspect. 1997 Sep;105 Suppl 5:1279-83. (PMID: 9400738) ; Environ Health Perspect. 1997 Sep;105 Suppl 5:1285-9. (PMID: 9400739) ; Atherosclerosis. 1999 Jan;142(1):169-78. (PMID: 9920518) ; Am J Clin Nutr. 1999 Jan;69(1):87-94. (PMID: 9925128) ; Am J Respir Crit Care Med. 1999 Mar;159(3):702-9. (PMID: 10051240) ; Environ Health Perspect. 1999 Mar;107(3):233-8. (PMID: 10064554) ; Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):981-8. (PMID: 10988117) Substance Nomenclature: 0 (Air Pollutants) ; 0 (Biomarkers) ; 0 (Blood Proteins) ; 0 (Hemoglobins) ; 7440-44-0 (Carbon) ; 9001-32-5 (Fibrinogen) Entry Date(s): Date Created: 20030208 Date Completed: 20030513 Latest Revision: 20220310 Update Code: 20240513 PubMed Central ID: PMC1241344

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Personal PM2.5 exposure and markers of oxidative stress in blood.