ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma.
In: Blood, Jg. 102 (2003-10-01), Heft 7, S. 2638-41
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Zugriff:
We present 3 cases of large B-cell lymphoma (LBCL) with a granular cytoplasmic staining for anaplastic lymphoma kinase (ALK). All of the cases showed striking similarities in morphology and immunohistochemical profile characterized by a massive monomorphic proliferation of CD20-/CD138+ plasmablast-like cells. In one of the cases, initially diagnosed as a null-type anaplastic large cell lymphoma (ALCL), the B-cell phenotype became evident only at recurrence. Fluorescent in situ hybridization (FISH) and molecular studies led to the detection of a CLTC-ALK rearrangement in all 3 cases, without any evidence of full-length ALK receptor expression. The associated t(2;17)(p23;q23) was demonstrated in the karyotype of 2 cases. Although a similar CLTC-ALK aberration was previously identified in ALK-positive T-/null cell ALCL and inflammatory myofibroblastic tumor, its association with ALK-positive LBCL seems to be specific and intriguing.
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ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma.
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Autor/in / Beteiligte Person: | De Paepe, P ; Baens, M ; van Krieken H ; Verhasselt, B ; Stul, M ; Simons, A ; Poppe, B ; Laureys, G ; Brons, P ; Vandenberghe, P ; Speleman, F ; Praet, M ; De Wolf-Peeters, C ; Marynen, P ; Wlodarska, I |
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Zeitschrift: | Blood, Jg. 102 (2003-10-01), Heft 7, S. 2638-41 |
Veröffentlichung: | 2021- : [New York] : Elsevier ; <i>Original Publication</i>: New York, Grune & Stratton [etc.], 2003 |
Medientyp: | academicJournal |
ISSN: | 0006-4971 (print) |
DOI: | 10.1182/blood-2003-04-1050 |
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