[Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer].
In: Molekuliarnaia biologiia, Jg. 37 (2003-11-01), Heft 6, S. 975-82
academicJournal
Zugriff:
Polymorphic alleles of CYP17 and CYP19, which are involved in estrogen biosynthesis, were tested for association with breast cancer (BC). Microsatellite (TTTA)n and 3-bp deletion of CYP19 and single-nucleotide polymorphism T27C of CYP17 were analyzed in 123 BC patients and 119 healthy women. Of the six (TTTA)n alleles observed, allele (TTTA)8 proved to be associated with BC (11.8% vs. 6.3%, P = 0.04). Genotype A2/A2 of CYP17 was also associated with BC (32.5% vs. 20.2%, P = 0.04). Risk of BC was especially high in the presence of both factors (7.3% vs. 0%, P < 0.01). Allele (TTTA)8 and genotype A2/A2 were assumed to be risk factors of BC.
| Titel: |
[Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer].
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| Autor/in / Beteiligte Person: | Artamonov, VV ; Liubchenko, LN ; Shabanov, MA ; Babenko, OV ; Nemtsova, MV ; Zaletaev, DV |
| Zeitschrift: | Molekuliarnaia biologiia, Jg. 37 (2003-11-01), Heft 6, S. 975-82 |
| Veröffentlichung: | Moskva : Izdatelstvo Nauka, 2003 |
| Medientyp: | academicJournal |
| ISSN: | 0026-8984 (print) |
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