Detection of microsatellite alterations in bronchial washings in squamous cell lung cancer: the first study from India.

Malhotra, P ; Behera, D ; et al.

In: Japanese journal of clinical oncology, Jg. 34 (2004-08-01), Heft 8, S. 439-44

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Background: In recent times, the possibility of detecting lung cancer using microsatellite alterations (microsatellite instability and loss of heterozygosity) in DNA of bronchial washings has been explored. However, no data regarding the presence of microsatellite alterations in lung cancer are available from India, a country which contributes significantly to the lung cancer burden of the world.

Methods: Bronchial washings as well as tumor specimens obtained on bronchoscopy were analyzed for the presence of loss of heterozygosity (LOH) and microsatellite instability (MSI) using the D3S1300 microsatellite marker on chromosome 3p and the TP53 marker on chromosome 17p.

Results: The sensitivities of the TP53 and D3S1300 loci in bronchial washings were 35% and 45% (combined 50%), respectively, which was significantly better than conventional cytology (positive for malignant cells in 15%). The presence of these microsatellite alterations was not related to the age, cumulative smoking exposure or smoking status (current or former) of patients.

Conclusion: Microsatellite alterations, particularly LOH, occur in a significant proportion of Indian patients with squamous cell carcinoma of the lung.

Titel:	Detection of microsatellite alterations in bronchial washings in squamous cell lung cancer: the first study from India.
Autor/in / Beteiligte Person:	Malhotra, P ; Behera, D ; Srinivasan, R ; Majumdar, S ; Wali, A ; Mir, S ; Kaur, R
Link:	Full Text Finder (Volltext)
Zeitschrift:	Japanese journal of clinical oncology, Jg. 34 (2004-08-01), Heft 8, S. 439-44
Veröffentlichung:	Oxford : Oxford University Press ; <i>Original Publication</i>: Tokyo, Foundation of Clinical Oncology., 2004
Medientyp:	academicJournal
ISSN:	0368-2811 (print)
DOI:	10.1093/jjco/hyh079
Schlagwort:	Acid Anhydride Hydrolases genetics Adult Aged Bronchoalveolar Lavage Fluid Chromosomes, Human, Pair 17 genetics Chromosomes, Human, Pair 3 genetics Female Humans India Male Middle Aged Neoplasm Proteins genetics Sensitivity and Specificity Tumor Suppressor Protein p53 genetics Carcinoma, Squamous Cell genetics DNA, Neoplasm genetics Loss of Heterozygosity Lung Neoplasms genetics Microsatellite Repeats
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article Language: English [Jpn J Clin Oncol] 2004 Aug; Vol. 34 (8), pp. 439-44. MeSH Terms: Loss of Heterozygosity* ; Microsatellite Repeats* ; Carcinoma, Squamous Cell / genetics ; DNA, Neoplasm / genetics ; Lung Neoplasms / *genetics ; Acid Anhydride Hydrolases / genetics ; Adult ; Aged ; Bronchoalveolar Lavage Fluid ; Chromosomes, Human, Pair 17 / genetics ; Chromosomes, Human, Pair 3 / genetics ; Female ; Humans ; India ; Male ; Middle Aged ; Neoplasm Proteins / genetics ; Sensitivity and Specificity ; Tumor Suppressor Protein p53 / genetics Substance Nomenclature: 0 (DNA, Neoplasm) ; 0 (Neoplasm Proteins) ; 0 (Tumor Suppressor Protein p53) ; 0 (fragile histidine triad protein) ; EC 3.6.- (Acid Anhydride Hydrolases) Entry Date(s): Date Created: 20040917 Date Completed: 20041116 Latest Revision: 20061115 Update Code: 20231215

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