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This research investigated the effect of glutamine (Gln) depletion on leucocyte-dependent inflammatory events. Rats were treated intraperitoneally, 16 hr prior to the peak of every parameter evaluated, with either 0.9% NaCl, methionine-sulphoximine (MSO, an inhibitor of endogenous Gln synthesis, 25 mg/kg) or with MSO + Gln (MSO as above plus Gln 3 g/kg in three doses). MSO-induced Gln depletion increased paw oedema induced both by carrageenan (Cg) and by Clostridium difficile toxin A (TxA) (66.2% and 45.5%, respectively; P < 0.05). In dextran-injected animals, oedema and myeloperoxidase (MPO) activity were not modified by Gln depletion. In Cg-treated paws, Gln depletion increased MPO activity by 44% (P < 0.05), interleukin-1beta (IL-1beta) and tumour necrosis factor-alpha (TNF-alpha) concentrations by 47% and 52%, respectively (P < 0.05), and immunostaining for TNF-alpha in paw tissue. In TxA-injected paws, Gln depletion increased MPO activity (46%; P < 0.05). Gln depletion increased Cg- and TxA-induced neutrophil migration to subcutaneous air pouches by 56% and 77% (P < 0.05), respectively, but did not affect migration induced by N-formyl-methionyl-leucyl-phenylalanine (fMLP). Gln infusions reversed all the effects of MSO. Leucocyte counts did not differ between groups. Gln depletion potentiates acute inflammation, possibly by increasing neutrophil migration through resident cell activation and production of IL-1beta and TNF-alpha. Gln supplementation reverses these effects and may be useful during inflammatory catabolic stress.

Titel:	Glutamine depletion potentiates leucocyte-dependent inflammatory events induced by carrageenan or Clostridium difficile toxin A in rats.
Autor/in / Beteiligte Person:	Nascimento, SB ; Sousa, RB ; Martins, MJ ; Souza Gomes, A ; Souza, MH ; Guerrant, RL ; Cunha, FQ ; Ribeiro, RA ; Brito, GA
Link:	Full Text Finder (Volltext)
Zeitschrift:	Immunology, Jg. 116 (2005-11-01), Heft 3, S. 328-36
Veröffentlichung:	Oxford : Blackwell Scientific Publications, 2005
Medientyp:	academicJournal
ISSN:	0019-2805 (print)
DOI:	10.1111/j.1365-2567.2005.02232.x
Schlagwort:	Animals Bacterial Toxins Carrageenan Edema chemically induced Edema immunology Enterotoxins Female Glutamine blood Glutamine deficiency Inflammation chemically induced Interleukin-1 biosynthesis Leukocyte Count Male Peroxidase metabolism Rats Rats, Wistar Tumor Necrosis Factor-alpha biosynthesis Glutamine immunology Inflammation immunology Neutrophil Infiltration immunology
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Immunology] 2005 Nov; Vol. 116 (3), pp. 328-36. MeSH Terms: Glutamine / immunology ; Inflammation / immunology ; Neutrophil Infiltration / *immunology ; Animals ; Bacterial Toxins ; Carrageenan ; Edema / chemically induced ; Edema / immunology ; Enterotoxins ; Female ; Glutamine / blood ; Glutamine / deficiency ; Inflammation / chemically induced ; Interleukin-1 / biosynthesis ; Leukocyte Count ; Male ; Peroxidase / metabolism ; Rats ; Rats, Wistar ; Tumor Necrosis Factor-alpha / biosynthesis References: Biochem J. 1986 Oct 1;239(1):121-5. (PMID: 3800971) ; Braz J Med Biol Res. 2003 Oct;36(10):1383-90. (PMID: 14502371) ; Am J Respir Crit Care Med. 1996 Dec;154(6 Pt 1):1843-50. (PMID: 8970379) ; Prostaglandins Med. 1979 Apr;2(4):293-7. (PMID: 583576) ; Am J Pathol. 1983 Jun;111(3):273-81. (PMID: 6305198) ; FEBS Lett. 1997 Aug 11;413(1):81-4. (PMID: 9287121) ; Clin Nutr. 2002 Oct;21(5):409-16. (PMID: 12381339) ; Arch Surg. 1992 Oct;127(10):1237-40. (PMID: 1358047) ; Comp Biochem Physiol B. 1988;91(4):789-92. (PMID: 2906283) ; Lancet. 1990 Sep 1;336(8714):523-5. (PMID: 1975037) ; Biochem J. 1991 Sep 1;278 ( Pt 2):471-4. (PMID: 1898339) ; J Nutr. 2001 May;131(5):1433-7. (PMID: 11340095) ; Nutrition. 1998 Mar;14(3):261-5. (PMID: 9583368) ; Blood. 1982 Sep;60(3):618-22. (PMID: 6286012) ; Biochem Pharmacol. 1980 Apr 1;29(7):1073-5. (PMID: 6155918) ; Pharmacol Toxicol. 2001 Jun;88(6):313-8. (PMID: 11453371) ; J Exp Med. 1956 Apr 1;103(4):399-412. (PMID: 13306850) ; Nature. 1981 Feb 19;289(5799):646-50. (PMID: 7464931) ; J Physiol. 1957 Jan 23;135(1):10-1P. (PMID: 13398984) ; J Infect Dis. 2002 May 1;185(9):1297-306. (PMID: 12001047) ; Scand J Gastroenterol Suppl. 1995;208:81-9. (PMID: 7777810) ; JPEN J Parenter Enteral Nutr. 2001 Nov-Dec;25(6):346-51. (PMID: 11688940) ; Proc Natl Acad Sci U S A. 1990 Apr;87(8):2921-5. (PMID: 2109319) ; Br J Pharmacol. 2003 Jul;139(6):1135-45. (PMID: 12871832) ; J Pharmacol Exp Ther. 1969 Mar;166(1):96-103. (PMID: 5776026) ; J Periodontol. 1993 May;64(5 Suppl):445-9. (PMID: 8315566) ; J Pathol. 1971 May;104(1):15-29. (PMID: 4398139) ; Eur J Appl Physiol Occup Physiol. 1979 Apr 12;41(1):61-72. (PMID: 446472) ; Cytokine. 2000 Aug;12(8):1288-91. (PMID: 10930315) ; Biochem J. 1983 Jun 15;212(3):835-42. (PMID: 6882397) ; Gut. 1997 Oct;41(4):487-93. (PMID: 9391247) ; Nutrition. 2000 May;16(5):323-9. (PMID: 10793298) ; Infect Immun. 1997 Jul;65(7):2740-6. (PMID: 9199444) ; Braz J Med Biol Res. 1999 Jan;32(1):15-21. (PMID: 10347763) ; J Chromatogr. 1984 Dec 7;336(1):93-104. (PMID: 6396315) ; J Cell Biochem. 1993 Dec;53(4):343-51. (PMID: 7905486) ; Ann Surg. 1989 Jan;209(1):57-62. (PMID: 2910215) ; J Pharmacol Toxicol Methods. 1994 Nov;32(3):139-47. (PMID: 7858307) ; Am J Physiol. 1997 Oct;273(4 Pt 1):C1124-9. (PMID: 9357754) ; J Nutr. 1999 Jan;129(1):57-62. (PMID: 9915876) ; Clin Sci (Lond). 1999 Jun;96(6):639-46. (PMID: 10334970) ; Ann Surg. 1980 Jul;192(1):78-85. (PMID: 7406567) ; Agents Actions. 1986 Jun;18(3-4):429-38. (PMID: 3463170) ; Crit Care Med. 1997 Oct;25(10):1727-32. (PMID: 9377890) ; J Pathol. 1983 Dec;141(4):483-95. (PMID: 6663391) ; Acta Physiol Scand. 1988 May;133(1):115-21. (PMID: 3227900) ; Biochem Soc Symp. 1987;54:145-62. (PMID: 3332991) ; Clin Sci (Lond). 1999 Jan;96(1):89-97. (PMID: 9857111) ; J Appl Physiol (1985). 2001 Jun;90(6):2403-10. (PMID: 11356807) ; Shock. 2001 Nov;16(5):398-402. (PMID: 11699081) ; Cytokine. 1998 Oct;10(10):790-4. (PMID: 9811533) ; Fed Proc. 1982 Jul;41(9):2588-95. (PMID: 6806127) ; J Clin Invest. 1988 Jun;81(6):1741-5. (PMID: 2838520) ; Immunology. 1991 Aug;73(4):472-7. (PMID: 1916898) ; World J Gastroenterol. 2003 Jun;9(6):1327-32. (PMID: 12800250) ; Nature. 1952 Mar 8;169(4297):415-6. (PMID: 14919584) ; Clin Microbiol Rev. 1988 Jan;1(1):1-18. (PMID: 3144429) ; J Biol Chem. 1996 Oct 4;271(40):24874-9. (PMID: 8926278) ; J Pathol. 1981 Jun;134(2):147-56. (PMID: 7019400) ; J Trauma. 1996 Oct;41(4):687-94; discussion 694-5. (PMID: 8858029) ; Methods Biochem Anal. 1980;26:1-45. (PMID: 7392958) Substance Nomenclature: 0 (Bacterial Toxins) ; 0 (Enterotoxins) ; 0 (Interleukin-1) ; 0 (Tumor Necrosis Factor-alpha) ; 0 (tcdA protein, Clostridium difficile) ; 0RH81L854J (Glutamine) ; 9000-07-1 (Carrageenan) ; EC 1.11.1.7 (Peroxidase) Entry Date(s): Date Created: 20051021 Date Completed: 20051213 Latest Revision: 20181113 Update Code: 20240513 PubMed Central ID: PMC1802418

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Glutamine depletion potentiates leucocyte-dependent inflammatory events induced by carrageenan or Clostridium difficile toxin A in rats.