Olfactory associative conditioning in infant rats with brain stimulation as reward: II. Norepinephrine mediates a specific component of the bulb response to reward.
In: Behavioral neuroscience, Jg. 105 (1991-12-01), Heft 6, S. 843-9
academicJournal
Zugriff:
One of the circuits modified by early olfactory learning is in the olfactory bulb. Specifically, response patterns of mitral-tufted cells are modified by associative conditioning during the early postnatal period. In addition, previous work has demonstrated that mitral-tufted cell single units respond to both olfactory conditioned stimuli and rewarding stimulation of the medial forebrain bundle-lateral hypothalamus (MFB-LH). The present study suggests that norepinephrine beta-receptor activation is required for early olfactory learning using MFB-LH stimulation as reward. Propranolol injected before odor-MFB-LH pairings blocks the acquisition of conditioned behavioral responses and their neural correlates to the conditioned odor. Furthermore, propranolol blocks a specific class of the mitral-tufted cell responses to MFB-LH reward stimulation. The relationship of this response to reward and early learning is discussed.
Titel: |
Olfactory associative conditioning in infant rats with brain stimulation as reward: II. Norepinephrine mediates a specific component of the bulb response to reward.
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Autor/in / Beteiligte Person: | Wilson, DA ; Sullivan, RM |
Zeitschrift: | Behavioral neuroscience, Jg. 105 (1991-12-01), Heft 6, S. 843-9 |
Veröffentlichung: | Washington, D.C. : American Psychological Association, [c1983-, 1991 |
Medientyp: | academicJournal |
ISSN: | 0735-7044 (print) |
DOI: | 10.1037//0735-7044.105.6.843 |
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