[Resistance to HIV-1 infection of CD4 + T lymphocytes in vitro from chinese HIV-1 exposed seronegative individuals].
In: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, Jg. 28 (2006-10-01), Heft 5, S. 613-7
academicJournal
Zugriff:
Objective: To determine the relative resistance to HIV-1 infection of CD4 + T lymphocytes in HIV-exposed seronegative individuals (ESNs) in China.
Methods: HIV primary isolates were obtained from peripheral whole blood of HIV-infected persons. CD4 + T lymphocytes of Chinese ESNs were separated from peripheral blood mononuclear cells with magnetic cell sorting (MACS). The purified CD4 + T lymphocytes were cocultured with HIV primary isolates. The p24 level was detected and the culture medium was refreshed every 3 days within 2 weeks.
Results: For M tropic HIV strains, p24 level was significantly lower in ESN group than in control group (P < 0.05); for some M tropic HIV strains, even no p24 replicated in ESN group. However, T tropic virus strains had no significant difference between these two groups (P > 0.05).
Conclusion: CD4 + T lymphocytes of Chinese ESNs may possess relative resistance to M tropic HIV strains, which may be one of the main influencing factors that result in ESN.
Titel: |
[Resistance to HIV-1 infection of CD4 + T lymphocytes in vitro from chinese HIV-1 exposed seronegative individuals].
|
---|---|
Autor/in / Beteiligte Person: | Su, YL ; Shang, H ; Liu, J ; Wang, SX ; Geng, WQ ; Cui, HL ; Jiang, YJ ; Wang, YN ; Zhang, ZN ; Wang, YT |
Zeitschrift: | Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, Jg. 28 (2006-10-01), Heft 5, S. 613-7 |
Veröffentlichung: | Beijing : Zhongguo yi xue ke xue yuan ; <i>Original Publication</i>: [Beijing] Zhongguo yi xue ke xue yuan., 2006 |
Medientyp: | academicJournal |
ISSN: | 1000-503X (print) |
Schlagwort: |
|
Sonstiges: |
|