TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues.
In: Blood, Jg. 109 (2007-05-15), Heft 10, S. 4328-35
Online
academicJournal
Zugriff:
The T-cell receptor zeta (TCRzeta) chain is a master sensor and regulator of lymphocyte responses. Loss of TCRzeta expression has been documented in infectious, inflammatory, and malignant diseases, suggesting that it may serve to limit T-cell reactivity and effector responses at sites of tissue damage. These observations prompted us to explore the relationship between TCRzeta expression and effector function in T cells. We report here that TCRzeta(dim) lymphocytes are enriched for antigen-experienced cells refractory to TCR-induced proliferation. Compared to their TCRzeta(bright) counterparts, TCRzeta(dim) cells share characteristics of differentiated effector T cells but use accessory pathways for transducing signals for inflammatory cytokine gene expression and cell contact-dependent pathways to activate monocytes. TCRzeta(dim) T cells accumulate in inflamed tissues in vivo and have intrinsic migratory activity in vitro. Whilst blocking leukocyte trafficking with anti-TNF therapy in vivo is associated with the accumulation of TCRzeta(dim) T cells in peripheral blood, this T-cell subset retains the capacity to migrate in vitro. Taken together, the functional properties of TCRzeta(dim) T cells make them promising cellular targets for the treatment of chronic inflammatory disease.
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TCRzetadim lymphocytes define populations of circulating effector cells that migrate to inflamed tissues.
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Autor/in / Beteiligte Person: | Zhang, Z ; Gorman, CL ; Vermi, AC ; Monaco, C ; Foey, A ; Owen, S ; Amjadi, P ; Vallance, A ; McClinton, C ; Marelli-Berg, F ; Isomäki, P ; Russell, A ; Dazzi, F ; Vyse, TJ ; Brennan, FM ; Cope, AP |
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Zeitschrift: | Blood, Jg. 109 (2007-05-15), Heft 10, S. 4328-35 |
Veröffentlichung: | 2021- : [New York] : Elsevier ; <i>Original Publication</i>: New York, Grune & Stratton [etc.], 2007 |
Medientyp: | academicJournal |
ISSN: | 0006-4971 (print) |
DOI: | 10.1182/blood-2006-12-064170 |
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