An acquired efflux system is responsible for copper resistance in Xanthomonas strain IG-8 isolated from China.

Ryan, RP ; Ryan, DJ ; et al.

In: FEMS microbiology letters, Jg. 268 (2007-03-01), Heft 1, S. 40-6

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The genus Xanthomonas contains plant pathogens exhibiting innate resistance to a range of antimicrobial agents. In other genera, multidrug resistance is mediated by a synergy between a low-permeability outer membrane and expression of a number of multidrug efflux systems. This report describes the isolation of a novel gene cluster xmeRSA from Xanthomonas strain IG-8 that mediates copper chloride resistance. Subsequent analysis of these genes showed that they were responsible for the high level of multiple resistance in this strain and were homologues of the sme system of Stenotrophomonas maltophilia. Knock-out mutants of this gene cluster indicate that these genes are required for the copper resistance phenotype of strain IG-8. Expression analysis using lacZ fusions indicates that the genes are regulated by copper and other antimicrobials. Bioinformatic analysis suggests that these genes were acquired by horizontal gene transfer.

Titel:	An acquired efflux system is responsible for copper resistance in Xanthomonas strain IG-8 isolated from China.
Autor/in / Beteiligte Person:	Ryan, RP ; Ryan, DJ ; Sun, YC ; Li, FM ; Wang, Y ; Dowling, DN
Link:	Full Text Finder (Volltext)
Zeitschrift:	FEMS microbiology letters, Jg. 268 (2007-03-01), Heft 1, S. 40-6
Veröffentlichung:	2015- : Oxford Oxford University Press ; <i>Original Publication</i>: Amsterdam, Published by Elsevier/North Holland on behalf of the Federation of European Microbiological Societies., 2007
Medientyp:	academicJournal
ISSN:	0378-1097 (print)
DOI:	10.1111/j.1574-6968.2006.00592.x
Schlagwort:	Bacterial Proteins genetics China Computational Biology Gene Expression Regulation, Bacterial Gene Transfer, Horizontal Membrane Transport Proteins genetics Microbial Sensitivity Tests Molecular Sequence Data Sequence Analysis, DNA Xanthomonas genetics Xanthomonas isolation & purification Bacterial Proteins metabolism Copper pharmacology Drug Resistance, Multiple, Bacterial Membrane Transport Proteins metabolism Multigene Family Xanthomonas drug effects
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [FEMS Microbiol Lett] 2007 Mar; Vol. 268 (1), pp. 40-6. MeSH Terms: Drug Resistance, Multiple, Bacterial* ; Multigene Family* ; Bacterial Proteins / metabolism ; Copper / pharmacology ; Membrane Transport Proteins / metabolism ; Xanthomonas / drug effects ; Bacterial Proteins / genetics ; China ; Computational Biology ; Gene Expression Regulation, Bacterial ; Gene Transfer, Horizontal ; Membrane Transport Proteins / genetics ; Microbial Sensitivity Tests ; Molecular Sequence Data ; Sequence Analysis, DNA ; Xanthomonas / genetics ; Xanthomonas / isolation & purification Molecular Sequence: GENBANK AY360452 Substance Nomenclature: 0 (Bacterial Proteins) ; 0 (Membrane Transport Proteins) ; 789U1901C5 (Copper) Entry Date(s): Date Created: 20070201 Date Completed: 20070316 Latest Revision: 20131121 Update Code: 20240513

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