No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population.

Ikeda, M ; Ozaki, N ; et al.

In: Schizophrenia research, Jg. 91 (2007-03-01), Heft 1-3, S. 22-6

academicJournal

Postmortem studies regarding schizophrenia revealed altered expression of genes related to gamma-amino butyric acid neurotransmission system. One of the most consistent findings is the reduced level of 67 kDa glutamic acid decarboxylase isoform (GAD(67)). Moreover, several studies reported positive associations between the GAD(67) gene (GAD1) and schizophrenia. These reasons, motivated us to carry out replication study regarding association between GAD1 (fourteen tagging SNPs) and schizophrenia in Japanese population (562 schizophrenic patients and 470 controls). However we couldn't confirm significant association that had been previously reported. Considering size of our sample and strategy that corresponds well with the approaches used in gene-based association analysis, our conclusion is that GAD1 does not play a major role in schizophrenia in Japanese population.

Titel:	No association between the glutamate decarboxylase 67 gene (GAD1) and schizophrenia in the Japanese population.
Autor/in / Beteiligte Person:	Ikeda, M ; Ozaki, N ; Yamanouchi, Y ; Suzuki, T ; Kitajima, T ; Kinoshita, Y ; Inada, T ; Iwata, N
Zeitschrift:	Schizophrenia research, Jg. 91 (2007-03-01), Heft 1-3, S. 22-6
Veröffentlichung:	Amsterdam : Elsevier Science Publisher B. V., c1988-, 2007
Medientyp:	academicJournal
ISSN:	0920-9964 (print)
DOI:	10.1016/j.schres.2006.12.020
Schlagwort:	Adolescent Adult Aged Aged, 80 and over Female Genetic Markers Genotype Haplotypes genetics Humans Japan Linkage Disequilibrium genetics Male Middle Aged Polymorphism, Single Nucleotide genetics gamma-Aminobutyric Acid metabolism Asian People genetics Asian People statistics & numerical data Gene Expression genetics Glutamate Decarboxylase genetics Glutamate Decarboxylase metabolism Isoenzymes genetics Isoenzymes metabolism Schizophrenia ethnology Schizophrenia genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: English Publication Type: Journal Article; Research Support, Non-U.S. Gov't Language: English [Schizophr Res] 2007 Mar; Vol. 91 (1-3), pp. 22-6. <i>Date of Electronic Publication: </i>2007 Feb 14. MeSH Terms: Asian People / genetics ; Asian People / statistics & numerical data ; Gene Expression / genetics ; Glutamate Decarboxylase / genetics ; Glutamate Decarboxylase / metabolism ; Isoenzymes / genetics ; Isoenzymes / metabolism ; Schizophrenia / ethnology ; Schizophrenia / *genetics ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Female ; Genetic Markers ; Genotype ; Haplotypes / genetics ; Humans ; Japan ; Linkage Disequilibrium / genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide / genetics ; gamma-Aminobutyric Acid / metabolism Substance Nomenclature: 0 (Genetic Markers) ; 0 (Isoenzymes) ; 56-12-2 (gamma-Aminobutyric Acid) ; EC 4.1.1.15 (Glutamate Decarboxylase) ; EC 4.1.1.15 (glutamate decarboxylase 1) Entry Date(s): Date Created: 20070217 Date Completed: 20070612 Latest Revision: 20221207 Update Code: 20231215

Klicken Sie ein Format an und speichern Sie dann die Daten oder geben Sie eine Empfänger-Adresse ein und lassen Sie sich per Email zusenden.

BibTeX Citavi, JabRef, u.a.
(Literaturverwaltung)

PDF kein Volltext!
(Merkzettel, Notizen)

RIS Endnote, Citavi u.a.
(Literaturverwaltung)

MODS
(XML zur Weiterverarbeitung)

oder

Wählen Sie das für Sie passende Zitationsformat und kopieren Sie es dann in die Zwischenablage, lassen es sich per Mail zusenden oder speichern es als PDF-Datei.

Gewünschter Zitations-Stil:

oder

Bitte prüfen Sie, ob die Zitation formal korrekt ist, bevor Sie sie in einer Arbeit verwenden. Benutzen Sie gegebenenfalls den "Exportieren"-Dialog, wenn Sie ein Literaturverwaltungsprogramm verwenden und die Zitat-Angaben selbst formatieren wollen.