Combined administration of NAN-190 and 17beta-estradiol abolishes the amnesic effect of scopolamine in middle-aged ovariectomized rats.
In: Bulletin of experimental biology and medicine, Jg. 142 (2006-07-01), Heft 1, S. 80-2
Online
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Zugriff:
Chronic combined administration of 5-HT1A receptor antagonist NAN-190 and 17beta-estradiol improved conditioned passive avoidance performance in middle-aged ovariectomized rats with scopolamine-induced amnesia. Our results suggest that the ovarian hormonal, cholinergic, and serotoninergic systems play a role in age-related cognitive disturbances under conditions of hypoestrogenic syndrome.
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Combined administration of NAN-190 and 17beta-estradiol abolishes the amnesic effect of scopolamine in middle-aged ovariectomized rats.
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Autor/in / Beteiligte Person: | Sapronov, NS ; Fedotova, YO ; Losev, NA |
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Zeitschrift: | Bulletin of experimental biology and medicine, Jg. 142 (2006-07-01), Heft 1, S. 80-2 |
Veröffentlichung: | New York : Springer ; <i>Original Publication</i>: New York, Consultants Bureau., 2006 |
Medientyp: | academicJournal |
ISSN: | 0007-4888 (print) |
DOI: | 10.1007/s10517-006-0297-7 |
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