[Study on relationship between polymorphism sites of TIM4 and allergic asthma in the population of Han nationality from Hubei province of China].

Xia, YP ; Cui, TP ; et al.

In: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, Jg. 24 (2007-04-01), Heft 2, S. 213-6

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Objective: To investigate two single nucleotide polymorphism sites of T cell immunoglobulin domain and mucin domain protein-4 (TIM4) and to detect their relationship with allergic asthma in a population of Hans from Hubei province of China.

Methods: The polymorphisms (8570G > A and 11515C > A) were detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 145 cases of allergic asthma and 130 healthy controls. The genotype and allele frequencies were calculated and analyzed.

Results: The genotype frequencies of GG, GA and AA in 8570G > A polymorphism were 0.985, 0.015 and 0 respectively in the healthy population and 0.931, 0.069 and 0 respectively in the allergic asthma population. There was significant difference in genotype and allele frequencies between the allergic asthma patients and control subjects (P=0. 030, P=0.032). The polymorphism of 11515C>o A was not detected.

Conclusion: The polymorphism of 8570G > A in TIM4 may be associated with allergic asthma in the population of Han nationality from Hubei province of China.

Titel:	[Study on relationship between polymorphism sites of TIM4 and allergic asthma in the population of Han nationality from Hubei province of China].
Autor/in / Beteiligte Person:	Xia, YP ; Cui, TP ; Wu, JM
Zeitschrift:	Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, Jg. 24 (2007-04-01), Heft 2, S. 213-6
Veröffentlichung:	<2004->: Chengdu, Sichuan, P.R. China : Sichuan University ; <i>Original Publication</i>: Chengdu : Hua xi yi ke da xue,, 2007
Medientyp:	academicJournal
ISSN:	1003-9406 (print)
Schlagwort:	Adolescent Adult Aged Asian People genetics Asthma ethnology Child Child, Preschool China Female Gene Frequency Genotype Humans Infant Male Middle Aged Polymerase Chain Reaction Polymorphism, Restriction Fragment Length Polymorphism, Single Nucleotide genetics Young Adult Asthma genetics Membrane Proteins genetics Polymorphism, Genetic genetics
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Chinese Publication Type: Journal Article Language: Chinese [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2007 Apr; Vol. 24 (2), pp. 213-6. MeSH Terms: Asthma / genetics ; Membrane Proteins / genetics ; Polymorphism, Genetic / *genetics ; Adolescent ; Adult ; Aged ; Asian People / genetics ; Asthma / ethnology ; Child ; Child, Preschool ; China ; Female ; Gene Frequency ; Genotype ; Humans ; Infant ; Male ; Middle Aged ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Polymorphism, Single Nucleotide / genetics ; Young Adult Substance Nomenclature: 0 (Membrane Proteins) ; 0 (TIMD4 protein, human) Entry Date(s): Date Created: 20070405 Date Completed: 20090327 Latest Revision: 20221207 Update Code: 20240513

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