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Purpose: We intravenously administered flomoxef sodium (FMOX) 0.5-3.5 hours before cataract surgery and measured the concentration of the agent in the aqueous humor to investigate its penetration into the aqueous humor and its efficacy in the prevention of postoperative endophthalmitis.

Methods: 56 patients who underwent cataract surgery were enrolled in this study. They received 1 g FMOX via a 20-minute intravenous drip beginning 0.5-3.5 hours before the operation. Aqueous humor was aspirated from the anterior chamber and assayed for FMOX concentration using high-performance liquid chromatography.

Results: The mean intraoperative FMOX concentrations in the patients' aqueous humor were 0.79 +/- 0.24 microg/ml (administered 3.5 hours before surgery)--1.47 0.79 microg/ml (administered 1.5 hours before surgery). These concentrations administered 0.5-3.0 hours before surgery sufficiently exceeded the minimum inhibitory concentration (MIC) 90 values against Staphylococcus epidermidis, Staphylococcus aureus and Propionibacterium acnes, but did not achieve the MIC90 values against Enterococcus faecalis and Pseudomonas aeruginosa.

Conclusions: The FMOX concentrations in the aqueous humor sampling were adequate to kill bacteria in vitro. This drug may be efficacious in the prevention of postoperative endophthalmitis in patients undergoing cataract surgery.

Titel:	[Preoperatively administered flomoxef sodium concentration in aqueous humor].
Autor/in / Beteiligte Person:	Miyamoto, M ; Watanabe, Y ; Mizuki, N
Zeitschrift:	Nippon Ganka Gakkai zasshi, Jg. 111 (2007-04-01), Heft 4, S. 326-30
Veröffentlichung:	Tokyo : Nihon Ganka Gakkai, 2007
Medientyp:	academicJournal
ISSN:	0029-0203 (print)
Schlagwort:	Aged Aged, 80 and over Endophthalmitis microbiology Female Humans Infusions, Intravenous Male Middle Aged Time Factors Anti-Bacterial Agents administration & dosage Anti-Bacterial Agents pharmacokinetics Antibiotic Prophylaxis Aqueous Humor metabolism Cataract Extraction Cephalosporins administration & dosage Cephalosporins pharmacokinetics Endophthalmitis prevention & control Postoperative Complications prevention & control Preoperative Care
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Japanese Publication Type: English Abstract; Journal Article Language: Japanese [Nippon Ganka Gakkai Zasshi] 2007 Apr; Vol. 111 (4), pp. 326-30. MeSH Terms: Antibiotic Prophylaxis* ; Cataract Extraction* ; Preoperative Care* ; Anti-Bacterial Agents / administration & dosage ; Anti-Bacterial Agents / pharmacokinetics ; Aqueous Humor / metabolism ; Cephalosporins / administration & dosage ; Cephalosporins / pharmacokinetics ; Endophthalmitis / prevention & control ; Postoperative Complications / *prevention & control ; Aged ; Aged, 80 and over ; Endophthalmitis / microbiology ; Female ; Humans ; Infusions, Intravenous ; Male ; Middle Aged ; Time Factors Substance Nomenclature: 0 (Anti-Bacterial Agents) ; 0 (Cephalosporins) ; V9E5U5XF42 (flomoxef) Entry Date(s): Date Created: 20070428 Date Completed: 20070612 Latest Revision: 20151008 Update Code: 20231215

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[Preoperatively administered flomoxef sodium concentration in aqueous humor].