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Background: Many drugs and the combinations of drugs are recommended for each treatment step in bronchial asthma. However, there are few issues examined about the optimal drug and combination of drugs in a long term prognosis. In this study, we investigated the optimal drugs and combinations of drugs from a point of view of prognosis.

Methods: One hundred and ninety four patients who visited our hospital for treatment from November, 2003 to October, 2004 and were managed according to GINA guideline were surveyed retrospectively. We compared the rate of step up and the frequency of urgent visit and urgent hospitalization in one year between drug groups in each treatment step.

Results: The rate of step up was significantly higher in leukotriene receptor antagonist (LTRA) group than in inhalation corticosteroid (ICS) group and theophylline group in Step 2. The frequency of urgent visit and urgent hospitalization was significantly higher in ICS+LTRA group than in ICS+theophylline group and ICS+long-acting beta 2-agonist (LABA) group in Step 3.

Conclusion: There is a possibility that the prognosis becomes bad when we use LTRA in the practical treatment according to GINA guideline.

Titel:	[Investigation of optimal drug in moderate bronchial asthma].
Autor/in / Beteiligte Person:	Kataoka, A ; Nishimura, N ; Uchiyama, N ; Ono, H ; Kishi, J ; Chonabayashi, N
Zeitschrift:	Arerugi = [Allergy], Jg. 56 (2007-07-01), Heft 7, S. 685-90
Veröffentlichung:	Tokyo : Nihon Allergy Gakkai ; <i>Original Publication</i>: Tokyo, Nippon Arerugi Gakkai., 2007
Medientyp:	academicJournal
ISSN:	0021-4884 (print)
Schlagwort:	Administration, Inhalation Adolescent Adult Aged Drug Administration Schedule Drug Therapy, Combination Female Humans Male Middle Aged Practice Guidelines as Topic Prognosis Retrospective Studies Adrenal Cortex Hormones administration & dosage Adrenergic beta-Agonists administration & dosage Asthma drug therapy Leukotriene Antagonists administration & dosage
Sonstiges:	Nachgewiesen in: MEDLINE Sprachen: Japanese Publication Type: English Abstract; Journal Article Language: Japanese [Arerugi] 2007 Jul; Vol. 56 (7), pp. 685-90. MeSH Terms: Adrenal Cortex Hormones / administration & dosage ; Adrenergic beta-Agonists / administration & dosage ; Asthma / drug therapy ; Leukotriene Antagonists / administration & dosage ; Administration, Inhalation ; Adolescent ; Adult ; Aged ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Humans ; Male ; Middle Aged ; Practice Guidelines as Topic ; Prognosis ; Retrospective Studies Substance Nomenclature: 0 (Adrenal Cortex Hormones) ; 0 (Adrenergic beta-Agonists) ; 0 (Leukotriene Antagonists) Entry Date(s): Date Created: 20070803 Date Completed: 20070907 Latest Revision: 20071115 Update Code: 20240513

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[Investigation of optimal drug in moderate bronchial asthma].